5-Methoxy-3,4-dihydro-2H-pyrrole

• CAS: 5264-35-7
• Catalog Number: ACM5264357
• Category: Other Products
• Molecular Weight: 99.13
• Molecular Formula: C₅H₉NO
• Synonyms: 5-methoxy-3,4-dihydro-2H-pyrrole, 2-methoxypyrroline, 2-Methoxy-1-pyrroline, 5264-35-7, SBB042854, NSC601819, SureCN693264, AC1L72DM, AC1Q4FC5, ARONIS24199, c-C4H6N(2-OCH3), CTK4J6224, MolPort-000-156-994, 2-methoxy-4,5-dihydro-3H-pyrrole, ANW-72188, STL299809, ZINC04268437, 2H-Pyrrole,3,4-dihydro-5-methoxy-, AKOS000269287, 2H-Pyrrole, 3,4-dihydro-5-methoxy-
• IUPAC Name: 5-methoxy-3,4-dihydro-2H-pyrrole
• Canonical SMILES: COC1=NCCC1
• InChI Key: QYGNDKJRRNVSEC-UHFFFAOYSA-N
• Boiling Point: 120.2ºC at 760mmHg
• Flash Point: 26.5ºC
• Density: 1.05g/cm³
• Exact Mass: 99.06840
• H-Bond Acceptor: 2
• H-Bond Donor: 0

Synthetic Use

Upstream Synthesis Route 1

• 616-45-5
• 77-78-1

• 5264-35-7

Reference: [1] Arkivoc, 2016, vol. 2016, # 5, p. 118 - 141

Upstream Synthesis Route 2

• 616-45-5
• 420-37-1

• 5264-35-7

Reference: [1] Organic Letters, 2012, vol. 14, # 18, p. 4906 - 4909,4
[2] Organic Letters, 2012, vol. 14, # 18, p. 4906 - 4909
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 19, p. 4359 - 4362

Upstream Synthesis Route 3

• 123-75-1
• 77-78-1

• 5264-35-7

Reference: [1] Patent: EP2848618, 2015, A1, . Location in patent: Paragraph 0895

Downstream Synthesis Route 1

• 5264-35-7
• 4114-31-2

• 116056-07-6

Reference: [1]Petersen; Tietze
[Chemische Berichte, 1957, vol. 90, p. 909,818]

Downstream Synthesis Route 2

• 5264-35-7
• 2033-24-1

• 70912-52-6

Reference: [1]Fasseur, Dominique; Rigo, Benoit; Leduc, Catherine; Cauliez, Pascal; Couturier, Daniel
[Journal of Heterocyclic Chemistry, 1992, vol. 29, # 5, p. 1285 - 1291]
[2]Brož, Břetislav; Růžičková, Zdeňka; Šimůnek, Petr
[Arkivoc, 2016, vol. 2016, # 5, p. 118 - 141]
[3]Celerier,J.P. et al.
[Journal of Organic Chemistry, 1979, vol. 44, p. 3089]
[4]Current Patent Assignee: SANOFI - US2003/92698, 2003, A1
[5]Current Patent Assignee: SANOFI - US2004/87570, 2004, A1

Downstream Synthesis Route 3

• 5765-44-6
• 5264-35-7

• 96600-79-2

Reference: [1]Tetrahedron Letters,1985,vol. 26,p. 259 - 262

* For details of the synthesis route, please refer to the original source to ensure accuracy.