4-Methoxyphenylacetic acid

• CAS: 104-01-8
• Catalog Number: ACM104018
• Category: Other Products
• Molecular Weight: 166.17
• Molecular Formula: C9H10O3
• Synonyms: p-Methioxy-toluicacid
• IUPAC Name: 2-(4-methoxyphenyl)acetic acid
• Canonical SMILES: COC1=CC=C(C=C1)CC(=O)O
• InChI: InChI=1S/C9H10O3/c1-12-8-4-2-7(3-5-8)6-9(10)11/h2-5H,6H2,1H3,(H,10,11)
• InChI Key: NRPFNQUDKRYCNX-UHFFFAOYSA-N
• Boiling Point: 140 °C /3mmHg (lit.)
• Melting Point: 84-86 °C (lit.)
• Density: 1.171 g/ml
• Appearance: White to off-yellow powder
• Solubility In Water: 6 g/L

Synthetic Use

Upstream Synthesis Route 1

• 6343-93-7

• 104-01-8

Reference: [1]Journal of Organic Chemistry,1940,vol. 5,p. 606,608

Downstream Synthesis Route 1

• 104-01-8

• 10338-51-9

Reference: [1] Chemical and Pharmaceutical Bulletin, 1998, vol. 46, # 4, p. 581 - 586

Downstream Synthesis Route 2

• 104-01-8

• 531-95-3

Reference: [1] Organic Letters, 2006, vol. 8, # 24, p. 5441 - 5443
[2] Tetrahedron, 2012, vol. 68, # 26, p. 5172 - 5178
[3] Journal of the American Chemical Society, 2012, vol. 134, # 44, p. 18245 - 18248
[4] Tetrahedron, 2018, vol. 74, # 16, p. 2020 - 2029

Downstream Synthesis Route 3

• 104-01-8

• 491-80-5

Reference: [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 2000, vol. 4, p. 567 - 570
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 9, p. 2962 - 2970

Downstream Synthesis Route 4

• 104-01-8

• 63304-80-3

Reference: [1]Patent: US2018/111905,2018,A1 .Location in patent: Paragraph 0327; 0328; 0329

Downstream Synthesis Route 5

• 104-01-8
• 77287-34-4

• 6343-93-7

Reference: [1]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1942,vol. 62,p. 532; engl. Ref. S. 169
Chem.Abstr.,1951,p. 2861

* For details of the synthesis route, please refer to the original source to ensure accuracy.