4-Hydroxyisophthalaldehyde

• CAS: 3328-70-9
• Catalog Number: ACM3328709-2
• Category: Other Products
• Molecular Weight: 150.13
• Molecular Formula: C8H6O3
• Synonyms: 2,4-Diformylphenol; 4-Hydroxybenzene-1,3-dicarbaldehyde
• IUPAC Name: 4-hydroxybenzene-1,3-dicarbaldehyde
• Canonical SMILES: C1=CC(=C(C=C1C=O)C=O)O
• InChI Key: FEUATHOQKVGPEK-UHFFFAOYSA-N
• Boiling Point: 266 °C at 760 mmHg
• Melting Point: 109 °C
• Appearance: Grey solid powder
• Exact Mass: 150.03200
• Hazard Statements: Xi
• H-Bond Acceptor: 3
• H-Bond Donor: 1
• Safety Description: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .; S36:Wear suitable protective clothing .
• WGK Germany: 3

Synthetic Use

Upstream Synthesis Route 1

• 100-97-0
• 90-02-8

• 3328-69-6
• 3328-70-9

Reference: [1] Research on Chemical Intermediates, 2015, vol. 41, # 11, p. 8147 - 8158

Upstream Synthesis Route 2

• 67-66-3
• 108-95-2

• 3328-69-6
• 3328-70-9
• 123-08-0
• 90-02-8

Reference: [1] Synthetic Communications, 1988, vol. 18, # 16-17, p. 2095 - 2102

Upstream Synthesis Route 3

• 23731-06-8

• 3328-70-9

Reference: [1]Applied Organometallic Chemistry,2010,vol. 24,p. 86 - 91

Upstream Synthesis Route 4

• 67-66-3
• 108-95-2

• 3328-69-6
• 3328-70-9
• 123-08-0
• 90-02-8

Reference: [1]Synthetic Communications,1988,vol. 18,p. 2095 - 2102

Downstream Synthesis Route 1

• 3328-70-9
• 70-11-1

• 120973-72-0

Reference: [1] Journal of Medicinal Chemistry, 2007, vol. 50, # 18, p. 4405 - 4418
[2] Tetrahedron Letters, 1996, vol. 37, # 52, p. 9267 - 9270
[3] Tetrahedron Letters, 1996, vol. 37, # 52, p. 9267 - 9270
[4] Heterocycles, 1997, vol. 45, # 7, p. 1363 - 1384
[5] Patent: EP299620, 1989, A1,

Downstream Synthesis Route 2

• 118-12-7
• 3328-70-9

• 20200-69-5

Reference: [1]Tetrahedron Letters,2000,vol. 41,p. 3915 - 3917
[2]Russian Journal of Bioorganic Chemistry,2008,vol. 34,p. 252 - 260
[3]Russian Chemical Bulletin,2014,vol. 63,p. 2026 - 2035
Izv. Akad. Nauk, Ser. Khim.,2014,p. 2026 - 2035,10
[4]Tetrahedron,1996,vol. 52,p. 8755 - 8762
[5]Chemical Communications,2002,p. 1398 - 1399

* For details of the synthesis route, please refer to the original source to ensure accuracy.