2-OCTYL CYANOACRYLATE

• CAS: 133978-15-1
• Catalog Number: ACM133978151
• Category: Main Products
• Molecular Weight: 209.28
• Molecular Formula: C12H19NO2
• Synonyms: Octan-2-yl 2-cyanoprop-2-enoate
• Appearance: Liquid

Case Study

Prospective Study of 2-Octylcyanoacrylate for Wound Closure

Wachter, Dorothee, et al. Neurosurgical review, 2010, 33(4), 483-489.

2-octylcyanoacrylate has been widely reported for postoperative wound closure, such as facial surgery, corneal surgery, orthopedic surgery, and hand surgery. This prospective study included 235 patients and evaluated the effect of 2-octylcyanoacrylate on wound closure in single-level and double-level spinal surgery.
Evaluation methods and results
· The preoperative and postoperative experiences of 235 patients were assessed, taking into account factors such as age, sex, body mass index, the duration and type of surgery, blood tests, a six-week follow-up, and an evaluation of preoperative risk factors. The findings were compared to infection rates for similar procedures reported in existing literature, as well as a historical group of 503 patients who had wound closure performed with standard skin sutures following spine surgery.
· With the application of 2-octyl-cyanoacrylate, only one patient developed a postoperative wound infection, resulting in an overall infection rate of 0.43%. According to literature on infection rates following spine surgery, the average is reported to be 3.2%, while the rate for the historical control group was found to be 2.2%.
· No risk factors were identified that would limit the use of 2-octyl-cyanoacrylate. Thus, 2-octyl-cyanoacrylate effectively provides adequate wound closure in spinal surgeries and is linked to a low incidence of postoperative wound infections.

Evaluation of 2-Octyl Cyanoacrylate Adhesive for Fixation of Autogenous Bone Grafts

Esteves, Jonatas Caldeira, et al. Journal of Oral Implantology, 2014, 40(4), 411-417.

The repair process of monolithic autologous bone grafts fixed with ethyl cyanoacrylate and 2-octyl cyanoacrylate adhesives in the rat skull was studied. The animals were randomly assigned to three experimental groups: Group I served as the Control; Group II received ethyl cyanoacrylate; and Group III was treated with 2-octyl cyanoacrylate. Each group consisted of eight animals and was observed for periods of 10 and 60 days. Round osteotomies were conducted on the right parietal bone to obtain autogenous bone graft fragments, which were then secured to the opposite side of the donor site using ethyl and 2-octyl cyanoacrylate adhesives. In the control group, the bone fragment was simply placed against the surface of the parietal bone without any fixation.
Qualitative analysis indicated a mild inflammatory infiltrate in the control group and a moderate infiltrate in both the ethyl and octyl groups at the 10-day mark, with these levels persisting at the 60-day follow-up, particularly in the octyl group. The adhesive successfully maintained the bond between the bone fragment and the recipient site; however, no incorporation of the graft was observed in any specimens. Resorption rates were highest in the octyl group, followed by the ethyl and control groups at both the 10- and 60-day evaluations, although these differences were not statistically significant (P < .05). While both adhesives facilitated the fixation and retention of the graft at the recipient site, they did not promote graft incorporation, leading to a localized, mild inflammatory response that continued at 60 days, particularly pronounced in the octyl cyanoacrylate group.