2-Hydroxyphenylacetic Acid

• CAS: 614-75-5
• Catalog Number: ACM614755
• Category: Other Products
• Molecular Weight: 152.15
• Molecular Formula: C8H8O3
• Synonyms: 2-Hydroxyphenylacetate
• IUPAC Name: 2-(2-Hydroxyphenyl)acetic acid
• Canonical SMILES: C1=CC=C(C(=C1)CC(=O)O)O
• InChI: InChI=1S/C8H8O3/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4,9H,5H2,(H,10,11)
• InChI Key: CCVYRRGZDBSHFU-UHFFFAOYSA-N
• Boiling Point: 240 °C
• Melting Point: 145-147 °C(lit.)
• Flash Point: 162.6 °C
• Density: 1.2143 g/cm³
• Solubility: Soluble in methanol, water
• Appearance: Crystalline powder
• Storage: Sealed in dry, room temperature
• Complexity: 144
• Exact Mass: 152.047344113
• Monoisotopic Mass: 152.047344113
• pKa: 4.17±0.10(Predicted)
• Refractive Index: 1.4945
• Topological Polar Surface Area: 57.5 Ų

Synthetic Use

Upstream Synthesis Route 1

• 103-82-2

• 156-38-7
• 621-37-4
• 614-75-5

Reference: [1] Tetrahedron Letters, 1983, vol. 24, # 44, p. 4847 - 4850
[2] Tetrahedron Letters, 1983, vol. 24, # 44, p. 4847 - 4850
[3] Bulletin of the Chemical Society of Japan, 1989, vol. 62, # 1, p. 148 - 152

Upstream Synthesis Route 2

• 103-82-2

• 156-38-7
• 621-37-4
• 451-13-8
• 64700-73-8
• 614-75-5

Reference: [1] Agricultural and Biological Chemistry, 1987, vol. 51, # 3, p. 947 - 948

Upstream Synthesis Route 3

• 271-89-6

• 7768-28-7
• 614-75-5

Reference: [1]Chemische Berichte,1901,vol. 34,p. 1808
Chemische Berichte,1902,vol. 35,p. 1631

Upstream Synthesis Route 4

• 118-93-4

• 614-75-5

Reference: [1]Patent: CN111057031,2020,A .Location in patent: Paragraph 0008; 0010; 0012; 0014; 0016; 0018

Downstream Synthesis Route 1

• 614-75-5
• 74-88-4

• 27798-60-3

Reference: [1] Patent: WO2005/75435, 2005, A1, . Location in patent: Page/Page column 138-139

Downstream Synthesis Route 2

• 67-56-1
• 614-75-5

• 22446-37-3

Reference: [1]Organic and Biomolecular Chemistry,2013,vol. 11,p. 5147 - 5155

* For details of the synthesis route, please refer to the original source to ensure accuracy.