2-Ethoxybenzhydrazide

• CAS: 21018-13-3
• Catalog Number: ACM21018133
• Category: Other Products
• Molecular Weight: 180.20
• Molecular Formula: C9H12N2O2
• Synonyms: 2-Ethoxybenzhydrazide, o-Ethoxy benzhydrazide, ZINC02146934, BBV-036667, 21018-13-3
• IUPAC Name: 2-ethoxybenzohydrazide
• Canonical SMILES: CCOC1=CC=CC=C1C(=O)NN
• InChI Key: LADUENYEZHMRQH-UHFFFAOYSA-N
• Melting Point: 62-64ºC
• Density: 1.144 g/cm³
• Appearance: white to pale yellow crystalline powder
• Exact Mass: 180.09000
• H-Bond Acceptor: 3
• H-Bond Donor: 2
• Safety Description: 26-36/37/39

Synthetic Use

Upstream Synthesis Route 1

• 6290-24-0

• 21018-13-3

Reference: [1] Patent: US2004/97505, 2004, A1,

Upstream Synthesis Route 2

• 134-11-2

• 21018-13-3

Reference: [1] Journal of Chemical Research, 2011, vol. 35, # 4, p. 234 - 237

Upstream Synthesis Route 3

• 3686-55-3

• 21018-13-3

Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 4, p. 1297 - 1303
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 11, p. 3615 - 3621
[3] European Journal of Medicinal Chemistry, 2014, vol. 87, p. 175 - 185
[4] Comptes Rendus Chimie, 2015, vol. 18, # 12, p. 1320 - 1327

Upstream Synthesis Route 4

• 6290-24-0

• 21018-13-3

Reference: [1]Current Patent Assignee: BAYER AG - US2004/97505, 2004, A1

Upstream Synthesis Route 5

• 3686-55-3

• 21018-13-3

Reference: [1]Skoumbourdis, Amanda P.; Huang, Ruili; Southall, Noel; Leister, William; Guo, Vicky; Cho, Ming-Hsuang; Inglese, James; Nirenberg, Marshall; Austin, Christopher P.; Xia, Menghang; Thomas, Craig J.
[Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 4, p. 1297 - 1303]
[2]Location in patent: scheme or table
Zhang, Li-Rong; Liu, Zhi-Jun; Zhang, Hui; Sun, Jian; Luo, Yin; Zhao, Ting-Ting; Gong, Hai-Bin; Zhu, Hai-Liang
[Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 11, p. 3615 - 3621]
[3]Nazreen, Syed; Alam, Mohammad Sarwar; Hamid, Hinna; Yar, Mohammad Shahar; Shafi, Syed; Dhulap, Abhijeet; Alam, Perwez; Pasha; Bano, Sameena; Alam, Mohammad Mahboob; Haider, Saqlain; Ali, Yakub; Kharbanda, Chetna; Pillai
[European Journal of Medicinal Chemistry, 2014, vol. 87, p. 175 - 185]
[4]Shi, Zhichuan; Zhao, Zhigang; Huang, Meiwei; Fu, Xiaolin
[Comptes Rendus Chimie, 2015, vol. 18, # 12, p. 1320 - 1327]

Upstream Synthesis Route 6

• 134-11-2

• 21018-13-3

Reference: [1]ChemMedChem,2020,vol. 15,p. 430 - 448