2,3,4,9-Tetrahydro-1H-carbazole-6-carboxylic acid

• CAS: 36729-27-8
• Catalog Number: ACM36729278
• Category: COVID-19 Drug Raw Materials
• Molecular Weight: 215.24
• Molecular Formula: C13H13NO2
• Synonyms: 2,3,4,9-Tetrahydro-1H-carbazole-6-carboxylic Acid
• IUPAC Name: 6,7,8,9-tetrahydro-5H-carbazole-3-carboxylic acid
• Canonical SMILES: C1CCC2=C(C1)C3=C(N2)C=CC(=C3)C(=O)O
• InChI: InChI=1S/C13H13NO2/c15-13(16)8-5-6-12-10(7-8)9-3-1-2-4-11(9)14-12/h5-7,14H,1-4H2,(H,15,16)
• InChI Key: OWQQDAGRTDUORV-UHFFFAOYSA-N
• Melting Point: 266-268 °C
• Appearance: Solid

Synthetic Use

Downstream Synthesis Route 1

• 36729-27-8

• 51035-17-7

Reference: [1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 27, p. 4832 - 4836

Downstream Synthesis Route 2

• 67-56-1
• 36729-27-8

• 302557-44-4

Reference: [1]Collar; Plant
[Journal of the Chemical Society, 1926, p. 809]
[2]Location in patent: scheme or table
Barf, Tjeerd; Lehmann, Fredrik; Hammer, Kristin; Haile, Saba; Axen, Eva; Medina, Carmen; Uppenberg, Jonas; Svensson, Stefan; Rondahl, Lena; Lundbaeck, Thomas
[Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 6, p. 1745 - 1748]
[3]Location in patent: scheme or table
Mittapalli, Gopi Kumar; Jackson, Andrew; Zhao, Fang; Lee, Haekyung; Chow, Stephine; McKelvy, Jeffrey; Wong-Staal, Flossie; MacDonald, James E.
[Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 22, p. 6852 - 6855]
Location in patent: scheme or table
Mittapalli, Gopi Kumar; Zhao, Fang; Jackson, Andrew; Gao, Hongfeng; Lee, Haekyung; Chow, Stephine; Kaur, Maninder Pal; Nguyen, Natalie; Zamboni, Robert; McKelvy, Jeffrey; Wong-Staal, Flossie; MacDonald, James E.
[Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 15, p. 4955 - 4961]
[4]Huang, Yafei; Yu, Mingcheng; Sun, Nannan; Tang, Ting; Yu, Fazhi; Song, Xiaoxia; Xie, Qiong; Fu, Wei; Shao, Liming; Wang, Yonghui
[European Journal of Medicinal Chemistry, 2018, vol. 148, p. 465 - 476]
[5]Current Patent Assignee: ITHERX PHARMACEUTICALS, INC. - WO2009/103022, 2009, A1
Location in patent: Page/Page column 30

Downstream Synthesis Route 3

• 64-17-5
• 36729-27-8

• 21660-16-2

Reference: [1]Alekseeva; Bokanov; Alekseeva; Granik
[Pharmaceutical Chemistry Journal, 2002, vol. 36, # 6, p. 318 - 323]
[2]Collar; Plant
[Journal of the Chemical Society, 1926, p. 809]
[3]Current Patent Assignee: ITHERX PHARMACEUTICALS, INC. - WO2008/21745, 2008, A2
Location in patent: Page/Page column 85-86

Downstream Synthesis Route 4

• 36729-27-8

• 51035-17-7

Reference: [1]Organic and Biomolecular Chemistry,2014,vol. 12,p. 4832 - 4836

* For details of the synthesis route, please refer to the original source to ensure accuracy.