1,2-Bis(chlorodimethylsilyl)ethane

• CAS: 13528-93-3
• Catalog Number: ACM13528933
• Category: Silylation Reagents
• Molecular Weight: 215.27
• Molecular Formula: C6H16Cl2Si2
• Synonyms: 1,1,4,4-Tetramethyl-1,4-dichloro-disilethylene, 2,5-Dichloro-2,5-dimethyl-2,5-disilahexane
• IUPAC Name: chloro-[2-[chloro(dimethyl)silyl]ethyl]-dimethylsilane
• Canonical SMILES: C[Si](C)(CC[Si](C)(C)Cl)Cl
• InChI Key: VGQOKOYKFDUPPJ-UHFFFAOYSA-N
• Boiling Point: 198 °C
• Melting Point: 35-38 °C(lit.)
• Flash Point: 68 °C
• Density: 0.97 g/mL
• Appearance: Clolorless liquid
• Storage: Moisture Sensitive. Ambient temperatures.
• EC Number: 236-871-0
• Exact Mass: 214.01700
• Hazard Statements: C:Corrosive
• H-Bond Acceptor: 0
• H-Bond Donor: 0
• Packaging: 10 g; 100 g
• Packing Group: III
• Physical State: Solid
• Safety Description: S16-S26-S36/37/39-S45
• WGK Germany: 3

Custom Reviews

2024-8-19

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Protecting Reagent for Primary Amines in my Research
I have been using 1,2-Bis(chlorodimethylsilyl)ethane from Alfa Chemistry as a protecting reagent for primary amines in my research project. It has been an essential component in my experiments, providing excellent yields and ease of preparation. The stability and facile removal of the tetramethyldisilylazacyclopentane or Stabase adducts have made it a valuable tool in my work, allowing for efficient protection of primary amines in my studies. I highly recommend this product for anyone working in the science research field.

Custom Q&A

What is the IUPAC name of the compound?

The IUPAC name of the compound is chloro-[2-[chloro(dimethyl)silyl]ethyl]-dimethylsilane.

What is the molecular formula of the compound?

The molecular formula of the compound is C6H16Cl2Si2.

What is the molecular weight of the compound?

The molecular weight of the compound is 215.26 g/mol.

What is the CAS number of the compound?

The CAS number of the compound is 13528-93-3.

How many hydrogen bond donor counts does the compound have?

The compound has 0 hydrogen bond donor count.

How many hydrogen bond acceptor counts does the compound have?

The compound has 0 hydrogen bond acceptor count.

How many rotatable bond counts does the compound have?

The compound has 3 rotatable bond count.

What is the exact mass of the compound?

The exact mass of the compound is 214.0167590 g/mol.

What is the topological polar surface area of the compound?

The topological polar surface area of the compound is 0Ų.

How many heavy atom counts does the compound have?

The compound has 10 heavy atom count.

Synthetic Use

Upstream Synthesis Route 1

• 1066-35-9
• 5356-83-2

• 13528-93-3

Reference: [1]Suryanarayanan,B. et al.
[Journal of Organometallic Chemistry, 1973, vol. 55, p. 65 - 71]

Downstream Synthesis Route 1

• 100-42-5
• 13528-93-3

• 27491-80-1

Reference: [1]Lu, Lingxiang; Siu, Juno C.; Lai, Yihuan; Lin, Song
[Journal of the American Chemical Society, 2020, vol. 142, # 51, p. 21272 - 21278]
[2]Steinmetz, Mark G.; Udayakumar, B. S.
[Journal of Organometallic Chemistry, 1989, vol. 378, p. 1 - 16]
[3]Callas,R.; Dunogues,J.
[Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1971, vol. 272, p. 554 - 557]

Downstream Synthesis Route 2

• 13528-93-3

• 20152-11-8

Reference: [1]Yang, Wenyu; Gao, Lu; Lu, Ji; Song, Zhenlei
[Chemical Communications, 2018, vol. 54, # 38, p. 4834 - 4837]
[2]Hanada, Shiori; Motoyama, Yukihiro; Nagashima, Hideo
[European Journal of Organic Chemistry, 2008, # 24, p. 4097 - 4100]
[3]Xie, Hengmu; Lu, Ji; Gui, Yingying; Gao, Lu; Song, Zhenlei
[Synlett, 2017, vol. 28, # 18, p. 2453 - 2459]
[4]Mironov,V.F. et al.
[Doklady Chemistry, 1968, vol. 179, p. 261 - 264][Doklady Akademii Nauk SSSR, 1968, vol. 179, p. 600 - 603]

* For details of the synthesis route, please refer to the original source to ensure accuracy.