methimazole

• CAS: 60-56-0
• Catalog Number: ACM60560
• Category: Imidazoles
• Molecular Weight: 114.16
• Molecular Formula: C4H6N2S
• Boiling Point: 280 °C
• Melting Point: 144-147 °C
• Density: 1.28 g/cm³
• Appearance: White solid

Custom Q&A

What is the molecular formula of methimazole?

The molecular formula of methimazole is C4H6N2S.

What is the molecular weight of methimazole?

The molecular weight of methimazole is 114.17 g/mol.

What is the role of methimazole?

Methimazole has a role as an antithyroid drug.

When was methimazole first introduced as an antithyroid agent?

Methimazole was first introduced as an antithyroid agent in 1949.

What is the mechanism of action of methimazole?

The mechanism of action of methimazole is as a Thyroid Hormone Synthesis Inhibitor.

Which drug is methimazole ten times more potent than on a weight basis?

Methimazole is ten times more potent than propylthiouracil on a weight basis.

Why is propylthiouracil preferred in pregnancy over methimazole?

Propylthiouracil is preferred in pregnancy over methimazole due to a perceived lower risk of teratogenic effects.

Which major antithyroid thionamide used in North America is methimazole more potent than?

Methimazole is more potent than propylthiouracil, another major antithyroid thionamide used in North America.

What is the InChIKey of methimazole?

The InChIKey of methimazole is PMRYVIKBURPHAH-UHFFFAOYSA-N.

What are some synonyms for methimazole?

Some synonyms for methimazole include thiamazole, Tapazole, and 2-Mercapto-1-methylimidazole.

Synthetic Use

Downstream Synthesis Route 1

• 186581-53-3
• 60-56-0

• 14486-52-3

Reference: [1] Patent: US5663164, 1997, A,

Downstream Synthesis Route 2

• 60-56-0
• 77-78-1

• 14486-52-3

Reference: [1] Magnetic Resonance in Chemistry, 1985, vol. 23, # 3, p. 166 - 169

Downstream Synthesis Route 3

• 60-56-0
• 74-88-4

• 14486-52-3

Reference: [1] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 1, p. 227 - 234
[2] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 1, p. 227 - 234

Downstream Synthesis Route 4

• 110-86-1
• 60-56-0
• 541-41-3

• 22232-54-8

Reference: [1]Journal of the Chemical Society,1956,p. 1103,1106

Downstream Synthesis Route 5

• 60-56-0
• 541-41-3

• 22232-54-8

Reference: [1]Journal of the Chemical Society,1956,p. 1103,1106

Downstream Synthesis Route 6

• 60-56-0
• 77-78-1

• 14486-52-3

Reference: [1]Magnetic Resonance in Chemistry,1985,vol. 23,p. 166 - 169

* For details of the synthesis route, please refer to the original source to ensure accuracy.