Lometrexol

• CAS: 106400-81-1
• Catalog Number: ACM106400811
• Category: Other Products
• Molecular Weight: 0
• Molecular Formula: C₂₁H₂₅N₅O₆
• Synonyms: Lometrexol;(6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid;N-[4-[2-[[(6R)-2-Amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin]-6-yl]ethyl]benzoyl]-L-glutamic acid;N-[4-[2-[[(R)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin]-6-yl]ethyl]benzoyl]-L-glutamic acid;L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-D)pyrimidin-6-yl)ethyl)benzoyl)-;L-Glutamic acid, N-(4-(2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-D)pyrimidin-6-yl)ethyl)benzoyl)-, (R)-;Lometrexolum;Lometrexolum [inn-latin]
• Hazard Statements: T
• Safety Description: 45
• Supplemental Hazard Statements: H301
• Symbol: GHS06

Custom Q&A

What is the molecular formula of Lometrexol?

The molecular formula of Lometrexol is C21H25N5O6.

What is the molecular weight of Lometrexol?

The molecular weight of Lometrexol is 443.5 g/mol.

What is the chemical structure of Lometrexol?

The chemical structure of Lometrexol is C21H25N5O6.

What is the therapeutic use of Lometrexol?

Lometrexol is used in trials for the treatment of Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, and Unspecified Adult Solid Tumor, Protocol Specific.

How does Lometrexol function as an antineoplastic agent?

Lometrexol is a folate analog antimetabolite that inhibits glycinamide ribonucleotide formyltransferase (GARFT), which is involved in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis and arresting cells in the S phase of the cell cycle.

What is the IUPAC name of Lometrexol?

The IUPAC name of Lometrexol is (2S)-2-[[4-[2-[(6R)-2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]amino]pentanedioic acid.

What is the InChIKey of Lometrexol?

The InChIKey of Lometrexol is ZUQBAQVRAURMCL-DOMZBBRYSA-N.

What is the Canonical SMILES representation of Lometrexol?

The Canonical SMILES representation of Lometrexol is C1C(CNC2=C1C(=O)NC(=N2)N)CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O.

What is the CAS number of Lometrexol?

The CAS number of Lometrexol is 106400-81-1.

What are some other identifiers associated with Lometrexol?

Other identifiers associated with Lometrexol include European Community (EC) Number, UNII, ChEMBL ID, DSSTox Substance ID, NCI Thesaurus Code, Nikkaji Number, Pharos Ligand ID, and Wikidata.