hydantoin

• CAS: 461-72-3
• Catalog Number: ACM461723
• Category: Imidazoles
• Molecular Weight: 100.07
• Molecular Formula: C3H4N2O2
• Melting Point: 218-220 °C
• Density: 1.356 g/cm³
• Appearance: White crystalline powder

Synthetic Use

Upstream Synthesis Route 1

• 97-59-6

• 461-72-3

Reference: [1]Justus Liebigs Annalen der Chemie,1861,vol. 117,p. 179
Justus Liebigs Annalen der Chemie,1864,vol. 130,p. 158

Downstream Synthesis Route 1

• 461-72-3

• 5918-93-4

Reference: [1] Synlett, 2013, vol. 24, # 18, p. 2443 - 2445
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 18, p. 5120 - 5123[3] Angew. Chem., 2018, vol. 130, p. 5214 - 5217,4
[4] Tetrahedron, 2008, vol. 64, # 1, p. 204 - 218
[5] Tetrahedron Letters, 1981, vol. 22, # 22, p. 2063 - 2066

Downstream Synthesis Route 2

• 461-72-3
• 120-92-3

• 699-51-4

Reference: [1] Journal of Medicinal Chemistry, 1999, vol. 42, # 14, p. 2504 - 2526

Downstream Synthesis Route 3

• 461-72-3
• 144-55-8
• 106412-35-5
• 28121-73-5

• 13625-39-3

Reference: [1] Patent: US6291469, 2001, B1,

Downstream Synthesis Route 4

• 461-72-3
• 120-89-8

• 6712-62-5

Reference: [1]Lin, Xin; Tago, Kenji; Okazaki, Nozomi; So, Takanori; Takahashi, Kyoko; Mashino, Tadahiko; Tamura, Hiroomi; Funakoshi-Tago, Megumi
[International Immunopharmacology, 2021, vol. 100]
[2]Buzzetti; Brasca; Crugnola; Fustinoni; Longo; Penco; Dalla Zonca; Comoglio
[Il Farmaco, 1993, vol. 48, # 5, p. 615 - 636]
[3]Mendgen, Thomas; Steuer, Christian; Klein, Christian D.
[Journal of Medicinal Chemistry, 2012, vol. 55, # 2, p. 743 - 753]
[4]Thenmozhiyal, Jeyanthi Chinnappa; Wong, Peter Tsun-Hon; Chui, Wai-Keung
[Journal of Medicinal Chemistry, 2004, vol. 47, # 6, p. 1527 - 1535]
[5]Boyd; Robson
[Biochemical Journal, 1935, vol. 29, p. 2256]
Shabica et al.
[Journal of the American Chemical Society, 1946, vol. 68, p. 1156]

* For details of the synthesis route, please refer to the original source to ensure accuracy.