Halobetasol propionate

• CAS: 66852-54-8
• Catalog Number: ACM66852548
• Category: Steroidal Compounds
• Molecular Weight: 484.96
• Molecular Formula: C₂₅H₃₁ClF₂O₅
• Synonyms: Uiobetasol Propionate; halobetasolpropionate; Miracorten; Halobetasol; ulobetasol propionate; halobetasol 17-propionate; Ultravate
• IUPAC Name: [(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]propanoate
• Canonical SMILES: CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)CCl
• InChI Key: BDSYKGHYMJNPAB-LICBFIPMSA-N
• Boiling Point: 570.7ºC at 760 mmHg
• Melting Point: 220 - 221ºC
• Flash Point: 298.9ºC
• Density: 1.31 g/cm³
• Appearance: Distributed as 0.05% ointment.
• Exact Mass: 484.18300
• Hazard Statements: T
• Packing Group: III
• Safety Description: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .; S36:Wear suitable protective clothing .; S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .; S7/9:Kee
• Stability: stable at normal temperatures and pressures.
• WGK Germany: 3

Custom Q&A

What is the molecular formula of Halobetasol propionate?

The molecular formula of Halobetasol propionate is C25H31ClF2O5.

What is the molecular weight of Halobetasol propionate?

The molecular weight of Halobetasol propionate is 485.0 g/mol.

What is the IUPAC name of Halobetasol propionate?

The IUPAC name of Halobetasol propionate is [(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate.

What are the synonyms of Halobetasol propionate?

The synonyms of Halobetasol propionate include HALOBETASOL PROPIONATE, 66852-54-8, Ulobetasol propionate, Ultravate, and Miracorten.

What are the other identifiers of Halobetasol propionate?

The other identifiers of Halobetasol propionate include CAS number 66852-54-8, European Community (EC) Number 686-247-0, UNII 91A0K1TY3Z, ChEMBL ID CHEMBL1200908, DSSTox Substance ID DTXSID6046636, KEGG ID D04409, NCI Thesaurus Code C47553, Nikkaji Number J2.508.879D, Pharos Ligand ID L7YSZU58GGSD, RXCUI 45318, Wikidata Q20817068, and Wikipedia Ulobetasol_propionate.

What is the description of Halobetasol propionate?

Halobetasol propionate is a corticosteroid hormone with anti-inflammatory, antipruritic, and vasoconstrictor activities. It is a topical steroid that reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability.

What are the computed properties of Halobetasol propionate?

The computed properties of Halobetasol propionate include molecular weight (485.0 g/mol), XLogP3 (3.7), hydrogen bond donor count (1), and hydrogen bond acceptor count (7).

How does Halobetasol propionate work?

Halobetasol propionate diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors, activating the expression of anti-inflammatory proteins. It inhibits the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation. This leads to the reduction of edema, erythema, and pruritus.

What are the chemical safety considerations for Halobetasol propionate?

Detailed chemical safety information about Halobetasol propionate is available in the Laboratory Chemical Safety Summary (LCSS) Datasheet.

When was Halobetasol propionate created and last modified?

Halobetasol propionate was created on July 28, 2006, and last modified on November 25, 2023.