Febuxostat

• CAS: 144060-53-7
• Catalog Number: ACM144060537
• Category: Other Products
• Molecular Weight: 316.37
• Molecular Formula: C₁₆H₁₆N₂O₃S
• Synonyms: FEBUXOSTAT;Tei-6720;2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid;2-[3-Cyano-4-isobutoxyphenyl]-4-methylthiazole-5-carboxylic acid;2-(3-Cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic Acid;2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid;TMX 67;Febuxosta
• Melting Point: 238-239°(dec.)

Custom Q&A

What is the chemical formula of Febuxostat?

The chemical formula of Febuxostat is C16H16N2O3S.

What is the molecular weight of Febuxostat?

The molecular weight of Febuxostat is 316.4 g/mol.

What is the mechanism of action of Febuxostat?

Febuxostat is a Xanthine Oxidase Inhibitor that works by inhibiting the activity of an enzyme responsible for the synthesis of uric acid.

What are the synonyms for Febuxostat?

Some synonyms for Febuxostat include Adenuric and Uloric.

When was Febuxostat created?

Febuxostat was created on June 24, 2005.

What is the black box warning added to Febuxostat based on?

The black box warning for Febuxostat was added based on the findings of a post-market clinical study (the CARES trial) showing an increased risk of cardiovascular (CV) fatal outcomes in patients with gout and known cardiovascular disease.

How is Febuxostat recommended to be used by health professionals according to the FDA?

The FDA advises health professionals to limit the use of Febuxostat to second-line therapy in patients who have inadequate response or intolerance to allopurinol and to avoid its use in patients with cardiovascular diseases.

What is the InChIKey for Febuxostat?

The InChIKey for Febuxostat is BQSJTQLCZDPROO-UHFFFAOYSA-N.

What is the CAS number for Febuxostat?

The CAS number for Febuxostat is 144060-53-7.

How does Febuxostat reduce serum uric acid levels in patients with gout?

Febuxostat reduces serum uric acid levels by inhibiting the activity of xanthine oxidase, the enzyme responsible for uric acid synthesis.

Synthetic Use

Upstream Synthesis Route 1

• 1139901-88-4

• 144060-53-7

Reference: [1]Canivet, Jerome; Yamaguchi, Junichiro; Ban, Ikuya; Itami, Kenichiro
[Organic Letters, 2009, vol. 11, # 8, p. 1733 - 1736]
[2]Yamamoto, Takuya; Muto, Kei; Komiyama, Masato; Canivet, Jerome; Yamaguchi, Junichiro; Itami, Kenichiro
[Chemistry - A European Journal, 2011, vol. 17, # 36, p. 10113 - 10122]
[3]Tsuchiya, Daisuke; Kawagoe, Yuhsuke; Moriyama, Katsuhiko; Togo, Hideo
[Organic Letters, 2013, vol. 15, # 16, p. 4194 - 4197]
[4]Tamura, Toshiyuki; Moriyama, Katsuhiko; Togo, Hideo
[European Journal of Organic Chemistry, 2015, vol. 2015, # 9, p. 2023 - 2029]
Nakai, Yuhta; Moriyama, Katsuhiko; Togo, Hideo
[European Journal of Organic Chemistry, 2014, vol. 2014, # 27, p. 6077 - 6083]
[5]Current Patent Assignee: JIANGXI SYNERGY PHARMACEUTICAL CO., LTD. - CN108358866, 2018, A
Location in patent: Paragraph 0150; 0151