Ecteinascidin 743

• CAS: 114899-77-3
• Catalog Number: ACM114899773
• Category: Other Products
• Molecular Weight: 761.845
• Molecular Formula: C₃₉H₄₃N₃O₁₁S
• Synonyms: ecteinascidin 743;Trabectedin;(1R,6R,6aR,7R,13S,14S,16R)-;ET-743;Yondelis;Trabectedin(Ecteinascidin 743,NSC-684766,ET-743, Yondelis);Ecteinascidin;Ecteinascidine 743
• Density: 1.55±0.1 g/cm³ (20 ºC 760 Torr)

Custom Q&A

What is the molecular formula of Trabectedin (Ecteinascidin 743)?

The molecular formula of Trabectedin (Ecteinascidin 743) is C39H43N3O11S.

What is the molecular weight of Trabectedin?

The molecular weight of Trabectedin is 761.8 g/mol.

What is the unique mechanism of action of Trabectedin?

Trabectedin binds to the minor groove of DNA interfering with cell division, genetic transcription processes, and DNA repair machinery.

Where was Trabectedin originally discovered?

Trabectedin was originally discovered in the Caribbean tunicate Ecteinascidia turbinata.

What is Trabectedin used for in medicine?

Trabectedin is used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.

How does Trabectedin interfere with cell division?

Trabectedin interferes with cell division by binding to the minor groove of DNA.

What are the synonyms for Trabectedin?

Some synonyms for Trabectedin include Yondelis, Ecteinascidin, and Ecteinascidin 743.

What regulatory approvals does Trabectedin have?

Trabectedin is approved for use in Europe, Russia, and South Korea for the treatment of advanced soft tissue sarcoma.

What is the IUPAC Name of Trabectedin?

The IUPAC name of Trabectedin is [(1R,2R,3R,11S,12S,14R,26R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxospiro[17,19,28- trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.1 3,11 .0 2,13 .0 4,9 .0 15,23 .0 16,20 ]triaconta-4(9),5,7,15,20,22-hexaene-26,1'-3,4-dihydro-2H-isoquinoline]-22-yl] acetate.

What is the InChIKey of Trabectedin?

The InChIKey of Trabectedin is PKVRCIRHQMSYJX-AIFWHQITSA-N.