Chlorotoxin

• CAS: 163515-35-3
• Catalog Number: ACM163515353
• Category: Other Products
• Molecular Weight: 4004.76
• Molecular Formula: C₁₅₈H₂₅₆N₅₂O₄₈S₁₁
• Synonyms: CHLOROTOXIN;CLTX;CLTX (EGYPTIAN SCORPION);H-MET-CYS-MET-PRO-CYS-PHE-THR-THR-ASP-HIS-GLN-MET-ALA-ARG-LYS-CYS-ASP-ASP-CYS-CYS-GLY-GLY-LYS-GLY-ARG-GLY-LYS-CYS-TYR-GLY-PRO-GLN-CYS-LEU-CYS-ARG-NH2;H-MET-CYS-MET-PRO-CYS-PHE-THR-THR-ASP-HIS-GLN-MET-ALA-ARG-LYS-CYS-ASP-ASP-CYS-CYS-GLY-GLY-LYS-GLY-ARG-GLY-LYS-CYS-TYR-GLY-PRO-GLN-CYS-LEU-CYS-ARG-NH2, (DISULFIDE BONDS BETWEEN CYS2 AND CYS19/CYS5 AND CYS28/CYS16 AND CYS33/CYS20 AND CYS35);H-MET-CYS-MET-PRO-CYS-PHE-THR-THR-ASP-HIS-GLN-MET-ALA-ARG-LYS-CYS-ASP-ASP-CYS-CYS-GLY-GLY-LYS-GLY-ARG-GLY-LYS-CYS-TYR-GLY-PRO-GLN-CYS-LEU-CYS-ARG-OH;MET-CYS-MET-PRO-CYS-PHE-THR-THR-ASP-HIS-GLN-MET-ALA-ARG-LYS-CYS-ASP-ASP-CYS-CYS-GLY-GLY-LYS-GLY-ARG-GLY-LYS-CYS-TYR-GLY-PRO-GLN-CYS-LEU-CYS-ARG-NH2;CHLOROTOXIN, RECOMBINANT, EXPRESSED
• Appearance: lyophilized powder

Case Study

The Potential of Chlorotoxin in Drug Design

Ojeda P G, et al. Peptide Science, 2016, 106(1): 25-36.

Chlorotoxin is a disulfide-rich stable peptide, and has several properties that make it a good starting point for drug design:
· It is able to bind preferentially to tumor cells, making the design of therapeutics using chlorotoxin as a scaffold to treat glioma and other types of cancer of neuroectodermal origin such as melanoma, neuroblastoma and medullobastoma possible.
· To date, no obvious toxicities nor immunogenic responses after being administered to humans have been reported
· Chlorotoxin is reportedly able to enter the brain and be internalized by cells, suggesting that it could be used to deliver drugs to the brain and/or intracellular targets.

Custom Q&A

What is the molecular formula of Chlorotoxin?

The molecular formula of Chlorotoxin is C158H249N53O47S11.

What is the molecular weight of Chlorotoxin?

The molecular weight of Chlorotoxin is 3996 g/mol.

What is the IUPAC name of Chlorotoxin?

The IUPAC name of Chlorotoxin is 2-[51,80,92-tris(4-aminobutyl)-5a-[(1-amino-5-carbamimidamido-1-oxopentan-2-yl)carbamoyl]-9-[(2-amino-4-methylsulfanylbutanoyl)amino]-39,62-bis(3-amino-3-oxopropyl)-24-benzyl-48,86-bis(3-carbamimidamidopropyl)-20a,33-bis(carboxymethyl)-27,30-bis(1-hydroxyethyl)-74-[(4-hydroxyphenyl)methyl]-36-(1H-imidazol-4-ylmethyl)-45-methyl-8a-(2-methylpropyl)-12,42-bis(2-methylsulfanylethyl)-a,3,7a,10,10a,13,15a,18a,19,21a,22,25,28,31,34,37,40,43,46,49,52,61,64,70,73,76,79,82,85,88,91,94,97-tritriacontaoxo-2a,3a,6,7,12a,13a,56,57-octathia-2,6a,9a,11,14,16a,19a,20,22a,23,26,29,32,35,38,41,44,47,50,53,60,63,69,72,75,78,81,84,87,90,93,96,99-tritriacontazahexacyclo[57.41.10.8 4,54 .4 21,77 .0 14,18 .0 65,69 ]docosahectan-17a-yl]acetic acid.

What is the InChI of Chlorotoxin?

The InChI of Chlorotoxin is InChI=1S/C158H249N53O47S11/c1-77(2)55-96-138(241)205-105(144(247)186-86(125(165)228)28-18-47-173-156(166)167)70-264-262-68-103-131(234)177-63-115(217)176-64-116(218)183-87(25-12-15-44-159)128(231)178-65-117(219)184-88(29-19-48-174-157(168)169)129(232)179-66-118(220)185-89(26-13-16-45-160)133(236)202-107-72-267-269-75-110-149(252)195-98(56-81-23-10-9-11-24-81)143(246)208-124(80(5)213)154(257)209-123(79(4)212)153(256)199-102(61-122(226)227)141(244)196-99(58-83-62-172-76-181-83)139(242)189-92(37-39-113(163)215)136(239)190-94(42-53-260-7)132(235)182-78(3)126(229)187-91(30-20-49-175-158(170)171)134(237)188-90(27-14-17-46-161)135...

What is the InChIKey of Chlorotoxin?

The InChIKey of Chlorotoxin is QPAKKWCQMHUHNI-UHFFFA.

When was Chlorotoxin created in PubChem?

Chlorotoxin was created in PubChem on April 21, 2021.

What is the synonym of Chlorotoxin?

The synonym of Chlorotoxin is AS-82547.

What is Chlorotoxin's potential anticancer property?

Chlorotoxin is a neurotoxin with potential anticancer property that binds preferentially to glioma cells and prevents the spread of tumor cells.

How is Chlorotoxin connected to the transmembrane endopeptidase matrix metalloproteinase-2 (MMP-2)?

Chlorotoxin binds preferentially to glioma cells via MMP-2, a transmembrane endopeptidase, which is specifically up-regulated in gliomas and related cancers.

In which clinical trial is Chlorotoxin under investigation?

Chlorotoxin is under investigation in clinical trial NCT00733798, which is a Safety and Efficacy Study of Intravenous 131I-TM601 in Adult Patients With Malignant Melanoma.