2,4-Dichloro-6-iodoquinazoline

CAS

74173-76-5

Catalog Number

ACM74173765

Category

Other Products

Molecular Weight

324.93329

Molecular Formula

C₈H₃Cl₂IN₂

MSDS COA Spec Sheet

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Specification

Synonyms

2,4-DICHLORO-6-IODOQUINAZOLINE;6-IODO-2,4-DICHLOROQUINAZOLINE

IUPAC Name

2,4-dichloro-6-iodoquinazoline

Canonical SMILES

C1=CC2=C(C=C1I)C(=NC(=N2)Cl)Cl

InChI Key

ZSIKVJNEGVNYIC-UHFFFAOYSA-N

Boiling Point

353.266ºC at 760 mmHg

Flash Point

167.45ºC

Density

2.083g/cm³

Exact Mass

323.87200

H-Bond Acceptor

H-Bond Donor

Upstream Synthesis Route 1

16353-27-8

74173-76-5

Reference: [1]Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
[Journal of Medicinal Chemistry, 1988, vol. 31, # 11, p. 2136 - 2145]
[2]Smits, Rogier A.; Adami, Maristella; Istyastono, Enade P.; Zuiderveld, Obbe P.; Van Dam, Cindy M. E.; De Kanter, Frans J. J.; Jongejan, Aldo; Coruzzi, Gabriella; Leurs, Rob; De Esch, Iwan J. P.
[Journal of Medicinal Chemistry, 2010, vol. 53, # 6, p. 2390 - 2400]
[3]Lee, Alex H. F.; Kool, Eric T.
[Journal of Organic Chemistry, 2005, vol. 70, # 1, p. 132 - 140]
[4]Current Patent Assignee: Gruenenthal Pharma GmbH & Co. Kommanditgesellschaft - US2009/69320, 2009, A1
Location in patent: Page/Page column 66
[5]Haffner, Curt D.; Becherer, J. David; Boros, Eric E.; Cadilla, Rodolfo; Carpenter, Tiffany; Cowan, David; Deaton, David N.; Guo, Yu; Harrington, Wallace; Henke, Brad R.; Jeune, Michael R.; Kaldor, Istvan; Milliken, Naphtali; Petrov, Kim G.; Preugschat, Frank; Schulte, Christie; Shearer, Barry G.; Shearer, Todd; Smalley, Terrence L.; Stewart, Eugene L.; Stuart, J. Darren; Ulrich, John C.
[Journal of Medicinal Chemistry, 2015, vol. 58, # 8, p. 3548 - 3571]

Downstream Synthesis Route 1

74173-76-5

116027-12-4

Reference: [1]Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
[Journal of Medicinal Chemistry, 1988, vol. 31, # 11, p. 2136 - 2145]