Structure

Boc-His(Tos)-OH

CAS
35899-43-5
Catalog Number
ACM35899435-1
Category
Amino Acids
Molecular Weight
409.46

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Specification

Description
Standard building block for introduction of histidine amino-acid residues by Boc SPPS.
Synonyms
Boc-His(Tos)-OH, N-α-t.-Boc-N-im-tosyl-L-histidine
InChI
1S/C18H23N3O6S/c1-12-5-7-14(8-6-12)28(25,26)21-10-13(19-11-21)9-15(16(22)23)20-17(24)27-18(2,3)4/h5-8,10-11,15H,9H2,1-4H3,(H,20,24)(H,22,23)/t15-/m0/s1
InChI Key
DCLJSEPKYJSEHW-HNNXBMFYSA-N
Application
Peptide synthesis.
Assay
≥98% (TLC)
≥98.0% (HPLC)
Form
powder
Functional Group
Boc
MDL Number
MFCD00065967
Quality Level
200
Reaction Suitability
reaction type: Boc solid-phase peptide synthesis
Storage Temperature
15-25℃

Upstream Synthesis Route 1

  • 98-59-9
  • 17791-52-5
  • 35899-43-5

Reference: [1] Journal of Medicinal Chemistry, 1993, vol. 36, # 17, p. 2431 - 2447

Downstream Synthesis Route 1

  • 15761-39-4
  • 13734-41-3
  • 13139-16-7
  • 13836-37-8
  • 73821-95-1
  • 47689-67-8
  • 35899-43-5
  • 4474-91-3

Reference: [1] Bioorganic Chemistry, 2011, vol. 39, # 2, p. 101 - 109

Downstream Synthesis Route 2

  • 2466-76-4
  • 13734-34-4
  • 13836-37-8
  • 35899-43-5
  • 110392-39-7

Reference: [1]Journal of Medicinal Chemistry,1987,vol. 30,p. 2126 - 2130

Downstream Synthesis Route 3

  • 2466-76-4
  • 13734-34-4
  • 35899-43-5
  • 110392-40-0

Reference: [1]Journal of Medicinal Chemistry,1987,vol. 30,p. 2126 - 2130

Downstream Synthesis Route 4

  • 21715-90-2
  • 35899-43-5
  • 74098-70-7

Reference: [1]Chemical and Pharmaceutical Bulletin,1981,vol. 29,p. 1644 - 1654

* For details of the synthesis route, please refer to the original source to ensure accuracy.

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