CB-103

CAS

218457-67-1

Catalog Number

ACM218457671-1

Category

Inhibitors

Molecular Weight

242.32

Molecular Formula

C15H18N2O

MSDS COA Spec Sheet

If you have any other questions or need other size, please get a quote.

Specification

Description

CB-103 is a γ-secretase inhibitor. CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis, thereby impairing proliferation, including in GSI-resistant human tumor cell lines with chromosomal translocations and rearrangements in Notch genes. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts, notably without causing the dose-limiting intestinal toxicity associated with other Notch inhibitors.

Synonyms

CB-103; CB 103; CB103

IUPAC Name

5-Amino-2-(4-tert-butylphenoxy)pyridine

Canonical SMILES

CC(C)(C)C1=CC=C(C=C1)OC2=NC=C(C=C2)N

InChI

InChI=1S/C15H18N2O/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14/h4-10H,16H2,1-3H3

InChI Key

WHIWGRCYMQLLAO-UHFFFAOYSA-N

Solubility

Soluble in DMSO

Appearance

Solid powder

Shelf Life

>2 years if stored properly

Storage

Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).

Drug Formulation

This drug may be formulated in DMSO

Elemental Analysis

C, 74.35; H, 7.49; N, 11.56; O, 6.60

Exact Mass

242.1419

HS Tariff Code

2934.99.9001

Shipping

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Stock Solution Storage

0-4 °C for short term (days to weeks), or -20 °C for long term (months).