Imiglucerase,>99% by HPLC analysis

CAS

154248-97-2

Catalog Number

ALC-FP-154248972

Category

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MSDS COA Spec Sheet

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Specification

Description

Imiglucerase is a hydrolytic lysosomal glucocerebrosidase-specific enzyme. It is ananalogue of the human enzyme b-glucocerebrosidase (b-D-glucosyl-N-acylsphingosineglucohydrolase, E.C. 3.2.1.45), produced by recombinant DNA technology usingmammalian cell culture (Chinese hamster ovary). Purified imiglucerase is a monomericglycoprotein of 497 amino acids, containing 4 N-linked glycosylation sites (Mr=60,430).Imiglucerase differs from placental glucocerebrosidase by one amino acid at position495, where histidine is substituted for arginine

Storage

Store at -20°C to -80°C

Concentration

1.0 mg/ml

Formulation

Each vial contains 42.4 units imiglucerase, mannitol (34 mg), polysorbate 80, NF (0.106mg), and sodium citrates: disodium hydrogen citrate (3.6 mg) and trisodium citrate (10.4mg).

Host

CHO

Sample Lot No.

A24C713R

Specification

Unit Definition

An enzyme unit (U) is defined as the amount of enzyme that catalyzes the hydrolysis of1 micromole of the synthetic substrate para-nitrophenyl-b-D-glucopyranoside (pNP-Glc)per minute at 37°C. Reconstituted solutions have a pH of approximately 6.1