1147737-68-5 Purity
97%
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An ion-sensitive field-effect transistor (ISFET) based on silicon nitride sensor (Si3N4) was developed, and triethoxysilane undecanal (TESUD) was further used to covalently bond the monoclonal antibody TNF-α (mAb anti- TNF-α) was addressed onto the Si3N4 surface to obtain an immune field effect transistor (ImmunoFET). The obtained sensor can be used for label-free detection of salivary Tumor necrosis factor-α (TNF-α) to monitor heart failure.
ISFET bio-functionalization with TESUD
· The process of bio-functionalizing the ISFETs began with cleaning them using acetone/ethanol in a sonicator bath, followed by thorough rinsing with Milli-Q water.
Next, the ISFETs were exposed to a UV/O3 cleaner for 30 minutes to activate the surface by introducing -OH groups onto the Si3N4 surface.
· The activated ISFETs were then functionalized with TESUD through a vapor-phase method. The devices were then heated in an oven at 100 °C for 1 hour, rinsed with absolute ethanol, and dried with nitrogen to remove excess TESUD.
· Subsequently, the functionalized ISFETs were treated with mAb anti-TNF-a in PBS and left in ethanolamine solution for 45 minutes at room temperature to prevent nonspecific bonding during the detection phase.
Novel silicon nitride-based structures (Si-p/SiO2/Si3N4) were created and their surfaces were treated with 11-(Triethoxysilyl)undecanal (TESUD) to activate them. They were then functionalized with polypyrrole (PPy) and coated with a polyvinylchloride (PVC)-membrane containing Aza[7]helicene as an ionophore to develop an ion-selective electrode (ISE). Electrochemical impedance spectroscopy (EIS) was used to test the sensitivity of the developed ISE to potassium ions, showing promising results.
Electrode preparation procedures
· The freshly cleaned Si3N4 substrates were immersed in a solution of TESUD dissolved in 20% ethanol for 30 minutes and then heated in a vacuum oven at 100°C for an hour to complete the silanization process. The substrates were then rinsed with absolute ethanol and dried with nitrogen gas.
· Next, the functionalized Si3N4 substrates were coated with a solution of pyrrole and SDS in ethanol, followed by stirring the mixture at room temperature for an hour. The polypyrrole (PPy) was grown onto the silane-functionalized surfaces through a condensation reaction between Py and the covalently bonded TESUD monolayer. FeCl3 was added to catalytically polymerize the PPy, after which the substrate was rinsed with absolute ethanol and dried with nitrogen gas.
The molecular formula of TRIETHOXYSILYLUNDECANAL is C17H36O4Si.
The synonyms of TRIETHOXYSILYLUNDECANAL are 11-triethoxysilylundecanal, 116047-42-8, 11-(triethoxysilyl)undecanal, triethoxysilylundecanal, and Undecanal, 11-(triethoxysilyl)-.
The molecular weight of TRIETHOXYSILYLUNDECANAL is 332.5 g/mol.
TRIETHOXYSILYLUNDECANAL was created on October 26, 2006.
The IUPAC name of TRIETHOXYSILYLUNDECANAL is 11-triethoxysilylundecanal.
The InChI of TRIETHOXYSILYLUNDECANAL is InChI=1S/C17H36O4Si/c1-4-19-22(20-5-2,21-6-3)17-15-13-11-9-7-8-10-12-14-16-18/h16H,4-15,17H2,1-3H3.
The Canonical SMILES of TRIETHOXYSILYLUNDECANAL is CCO[Si](CCCCCCCCCCC=O)(OCC)OCC.
The CAS number of TRIETHOXYSILYLUNDECANAL is 116047-42-8.
TRIETHOXYSILYLUNDECANAL has 17 rotatable bonds.
Yes, TRIETHOXYSILYLUNDECANAL is a canonicalized compound.