Bis-(tetramethylammonium)oxalate

CAS

98296-17-4

Catalog Number

ACM98296174

Category

Main Products

Molecular Weight

236.31

Molecular Formula

C₁₀H₂₄N₂O₄

MSDS COA Spec Sheet

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Specification

Synonyms

tetramethyl-ammonium,oxalate; Tetramethyl-ammonium,Oxalat;

IUPAC Name

oxalate;tetramethylazanium

Canonical SMILES

C[N+](C)(C)C.C[N+](C)(C)C.C(=O)(C(=O)[O-])[O-]

InChI Key

DAZMQARMQFEKQY-UHFFFAOYSA-L

EC Number

619-333-3

Exact Mass

162.07700

Suppression of wild-type amplification PCR assay using the selective enhancer Bis-(tetramethylammonium)oxalate

Structure of a SuperSelective primer bound to its mutant target fragment, and structure of the molecular beacon that will light up the resulting amplicons

Vargas, Diana Y., et al. The Journal of Molecular Diagnostics 20.4 (2018): 415-427.

In PCR assays for detecting rare somatic mutations, super-selective primers, by virtue of their short 3' sequence, selectively initiate the synthesis of the mutated DNA target fragment while inhibiting the synthesis of the associated wild-type fragment, resulting in The threshold cycle reflects the number of mutated targets present. However, when there are 10 or fewer mutant target fragments in the sample, the threshold cycles observed occur so late that they may be confused with threshold cycles produced by samples containing only a large number of relevant wild-type fragments. We report here that the addition of the selectivity enhancer tetramethylammonium chloride or Bis-(tetramethylammonium)oxalate to a superselective PCR assay significantly inhibits the amplification of the relevant wild-type fragment. Due to this selective inhibition, detection sensitivity is improved to such an extent that multiplex PCR testing can be performed in which false-positive or false-negative results are extremely unlikely. This advance opens the door to the development of rapid, low-cost, Multiplex PCR test lays foundation for non-invasive assessment of presence of relevant mutations in cancer patients, enabling personalized treatment
Bis-(tetramethylammonium)oxalate(TMAO) has also been identified as a hybridization-specific enhancer for classical PCR assays. 10 Therefore, the selectivity-enhancing effect of TMAO was compared with TMAC in a superselective PCR assay to evaluate the selectivity of TMAO when the relevant hybrid is formed from the short foot sequence of the superselective primer. Multiple samples containing 100,000 KRAS G12A mutant templates or 100,000 KRAS wild-type templates were prepared. These samples were tested in a real-time PCR assay containing 60 nM KRAS G12A 32-28-14/12-8:1:0 primer and 500 nM KRAS reverse primer. One set of reactions contained 0, 20, 40, 60, or 80 mM TMAC, and another set of reactions contained 0, 1.0, 1.5, 2.0, 2.5, or 3.0 mM TMAO. The results are summarized in Figure 7. Essentially, both TMAO and TMAC selectively inhibit amplification of the wild-type template, although the effective concentration of TMAO (up to 2.0 mM) is much lower than that of TMAC (up to 60 mM). exist

Bis-(tetramethylammonium)oxalate as a porogen for supercapacitors

TGA mass spectrum of (a) TMAO (b) As-spun PAN (T0) (c) As-spun PAN-TMAO (T10)

Perananthan, Sahila, Jeliza S. Bonso, and John P. Ferraris. Carbon 106 (2016): 20-27.

Thermosensitive Bis-(tetramethylammonium)oxalate (TMAO) was incorporated as an in-situ porogen into free-standing polyacrylonitrile (PAN) nonwoven nanofibers produced by electrospinning. Supercapacitor electrode materials were prepared by subjecting these fibers to a series of thermal treatments, including stabilization, followed by single-step carbonization, and CO2 activation. The specific surface area of the resulting carbon nanofibers (CNFs) was controlled by varying the TMAO content in the precursor fibers. The electrochemical properties of the carbon nanofibers were characterized by cyclic voltammetry and galvanostatic charge-discharge tests. PAN with 0.1 wt% TMAO (T10) achieved the highest surface area (2663 m2 g-1) and the best electrochemical performance, yielding a maximum specific capacitance of 140 F g-1 at a scan rate of 10 mV s-1, compared to 90 F g-1 for CNF made from PAN alone. Energy and power densities of 68 Wh kg-1 and 1.7 W kg-1 were achieved at a discharge current density of 1 A g-1, respectively, with a capacitance retention of 80% after 1000 cycles.
Different amounts of TMAO were dissolved in an equal amount of water (0.04 wt%) and dispersed in DMF by ultrasonication for 1 h and then mechanically stirred overnight. Polyacrylonitrile (PAN, 1.00 g, 10 wt%) was dissolved in the dispersion at 50 °C for one hour and stirred overnight at room temperature. A PAN (10 wt%) solution without TMAO was prepared as a control. We refer to the samples doped with 0.05 wt% and 0.1 wt% TMAO as T5 and T10, respectively, and pure PAN as T0. The solution was electrospun through a 20G spinneret at an applied voltage of 15 kV (Gamma High Voltage Research, Inc., power source). The fibers were placed on a grounded collector rotating at 300 rpm. The applied voltage, the distance between the needle tip and the collection drum (15 cm), and the speed of the collection drum were kept constant for all samples.

What is the molecular formula of Bis-(tetramethylammonium)oxalate?

The molecular formula is C10H24N2O4.

What are some synonyms for Bis-(tetramethylammonium)oxalate?

Some synonyms include tetramethylammonium oxalate and tetramethylammoniumoxalate.

What is the molecular weight of Bis-(tetramethylammonium)oxalate?

The molecular weight is 236.31 g/mol.

What are the component compounds of Bis-(tetramethylammonium)oxalate?

The component compounds are Tetramethylammonium (CID 6380) and Oxalic Acid (CID 971).

What is the IUPAC Name of Bis-(tetramethylammonium)oxalate?

The IUPAC Name is oxalate;tetramethylazanium.

What is the InChIKey of Bis-(tetramethylammonium)oxalate?

The InChIKey is DAZMQARMQFEKQY-UHFFFAOYSA-L.