Original Article:
1. Simple preparation of maltose-functionalized dendrimer/graphene quantum dots as a pH-sensitive biocompatible carrier for targeted delivery of doxorubicin;
2. Hydrophilic maltose-modified magnetic metal-organic framework for highly efficient enrichment of N-linked glycopeptides
1. Soheyla Karimi, et al. 2. Junyu Lu, et al.
1. International Journal of Biological Macromolecules, 2020, 156, 648-659. 2. Journal of Chromatography A, 2020, 1615, 460754.
1. 10.1016/j.ijbiomac.2020.04.037; 2. 10.1016/j.chroma.2019.460754
Maltose is a disaccharide composed of two glucose units linked by α-1,4 glycosidic bonds, also known as maltobiose. In addition to its application in the traditional food industry, the functional application of maltose in the research of biomedical materials has also been gradually explored, such as for drug delivery and the detection and identification of low-abundance N-linked glycopeptides.
Maltose-functionalized carrier for targeted delivery
Soheyla Karimi et al. used the molecule as a green capping agent to prepare a novel magnetic carrier for doxorubicin (DOX) drug delivery. In this work, maltose was used as an inert material to form an inert coating to formulate a chemically stable protection strategy for magnetic nanoparticles. The researchers deposited a layer of maltose on the magnetic core, and subsequently the maltose surface could be easily functionalized with various organic compounds, such as dendrimers. The results demonstrated that obtained microspheres can be used as a new safe and efficient vehicle for the delivery of different cancer drugs.
Maltose functionalized material for enrichment of glycopeptides
The method based on hydrophilic interaction liquid chromatography (HILIC) has many advantages such as mild enrichment conditions, high enrichment efficiency, high selectivity, wide glycan adaptability, and good mass spectrometry compatibility, which is a promising method for glycopeptide enrichment. Junyu Lu et al. developed a novel HILIC-based material based on the functionalization of hydrophilic maltose to efficiently enrich glycopeptides. In this work, the hydrophilic substance thiol-functionalized maltose (maltose-SH) was first synthesized and then used for subsequent magMOF@Au-maltose nanocomposite synthesis as shown in the figure. The findings suggest that magMOF@Au-maltose has promising applications in the detection and identification of low-abundance N-linked glycopeptides in complex biological samples.
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