4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

• CAS: 183322-18-1
• Catalog Number: ACM183322181
• Category: Other Products
• Molecular Weight: 312.75
• Molecular Formula: C₁₄H₁₇ClN₂O₄
• Synonyms: 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline;4-Chloro-6,7-(2-methoxyethoxy)quinazoline;4-Chloro-6,7-bis(2-methoxyethoxy)quinazolin;6,7-Bis(2-methoxyethoxy)-4-chloroquinazoline;Erlotinib Intermediate 1;4-chloro-6,7-di(2-methoxyethoxy)quinazoline;CP-335963;PF-508367
• Melting Point: 105-107 °C
• Density: 1.257
• Hazard Statements: Xn
• Safety Description: 26-39
• Supplemental Hazard Statements: H302-H318
• Symbol: GHS05,GHS07

Synthetic Use

Upstream Synthesis Route 1

• 179688-29-0

• 183322-18-1

Reference: [1]Seimbille, Yann; Phelps, Michael E.; Czernin, Johannes; Silverman, Daniel H. S.
[Journal of labelled compounds and radiopharmaceuticals, 2005, vol. 48, # 11, p. 829 - 843]

Upstream Synthesis Route 2

• 179688-29-0

• 183322-18-1

Reference: [1]Nakamura, Hiroyuki; Onagi, Shinya
[Tetrahedron Letters, 2006, vol. 47, # 15, p. 2539 - 2542]
[2]Zhang, Gengzhen; Zha, Linlin
[Research on Chemical Intermediates, 2013, vol. 39, # 6, p. 2303 - 2309]
[3]Current Patent Assignee: SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD.; CHINA NATIONAL PHARMACEUTICAL GROUP CORPORATION - US2011/288086, 2011, A1
Location in patent: Page/Page column 29
[4]Current Patent Assignee: SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD.; CHINA NATIONAL PHARMACEUTICAL GROUP CORPORATION - EP2592083, 2013, A1
Location in patent: Paragraph 0261
[5]Chen, Zhe-Sheng; Dai, Qing-Qing; Li, Guo-Bo; Liu, Hong-Min; Liu, Hui; Wang, Bo; Wang, Shaomeng; Yu, Bin; Yuan, Shuo; Zhang, Jing-Ya; Zhang, Xiao-Nan; Zuo, Jia-Hui
[Journal of Medicinal Chemistry, 2021, vol. 64, # 19, p. 14895 - 14911]

Downstream Synthesis Route 1

• 54060-30-9
• 183322-18-1

• 179688-29-0
• 183319-69-9

Reference: [1] Patent: WO2011/76813, 2011, A1, . Location in patent: Page/Page column 19

Downstream Synthesis Route 2

• 54060-30-9
• 183322-18-1

• 183319-69-9

Reference: [1]Journal of the Chemical Society. Perkin Transactions 2 (2001),2000,p. 2498 - 2502

* For details of the synthesis route, please refer to the original source to ensure accuracy.