1,2-Dibenzoyl-1-(T-Butyl)Hydrazine

• CAS: 112225-87-3
• Catalog Number: ACM112225873
• Category: Main Products
• Molecular Weight: 296.36
• Molecular Formula: C₁₈H₂₀N₂O₂
• Synonyms: N,N-dibenzoyl-N-(tert-butyl)-hydrazine; yishijing; N-benzoyl-N-(tert-butyl)benzenecarbohydrazide; N-benzoyl-N-tert-butyl-benzohydrazide; RH 5849; 1,2-Dibenzoyl-1-tert-butylhydrazine; N-tert-butyl-N-benzoylbenzohydrazide; Benzoic acid,2-benzoyl-1-(1,1-dimethylethyl)hydrazide; N'-benzoyl-N-tert-butylbenzohydrazide; benzoic acid 2-benzoyl-1-(1,1-dimethylethyl)hydrazide; N-benzoyl-N-tert-butylbenzohydrazide; benzoic acid N-benzoyl-N-tert-butylhydrazide; N-tert-butyl-N,N-dibenzoylhydrazine
• IUPAC Name: N'-benzoyl-N'-tert-butylbenzohydrazide
• Canonical SMILES: CC(C)(C)N(C(=O)C1=CC=CC=C1)NC(=O)C2=CC=CC=C2
• InChI Key: NISLLQUWIJASOV-UHFFFAOYSA-N
• Density: 1.128g/cm³
• Appearance: White powder
• Exact Mass: 296.15200

Case Study

Effects of RH5849 and Mifepristone on Female Drosophila Lifespan

Gary N. Landis, et al. Fly, 2022, 16(1), 397-413.

Ecdysone is a Drosophila steroid hormone reported to regulate mating responses. 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine (RH5849) is a synthetic ecdysone agonist and a potent mimetic of ecdysone. Studies have explored the lifespan effects of RH5849 on virgin females fed 1000 µg/ml in the presence and absence of 200 µg/ml mifepristone. The results are as follows:
· Administration of 200 µg/ml mifepristone alone led to an expected increase in life span (+23.5% and +26.1%, respectively).
· Conversely, treatment with 1000 µg/ml RH5849 alone resulted in a significant decrease in life span (-79.4% and -78.5%, respectively).
· However, when co-treated with 200 µg/ml mifepristone, a substantial rescue in life span was observed (+136% and +157%, respectively).
· To eliminate the possibility that the increased life span from mifepristone was due to reduced food intake, the EXQ assay was used to measure food consumption. Administration of 1000 µg/ml RH5849 led to a decrease of approximately 75% in food intake, while mifepristone did not impact food intake, suggesting that the rescue in life span by mifepristone was not a result of decreased food or drug intake.

Custom Q&A

What is the molecular formula of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine?

The molecular formula of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine is C18H20N2O2.

What is the molecular weight of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine?

The molecular weight of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine is 296.4 g/mol.

What is the IUPAC name of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine?

The IUPAC name of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine is N'-benzoyl-N-(tert-butyl)benzohydrazide.

What is the InChI of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine?

The InChI of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine is InChI=1S/C18H20N2O2/c1-18(2,3)20(17(22)15-12-8-5-9-13-15)19-16(21)14-10-6-4-7-11-14/h4-13H,1-3H3,(H,19,21).

What is the InChIKey of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine?

The InChIKey of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine is NISLLQUWIJASOV-UHFFFAOYSA-N.

What is the CAS number of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine?

The CAS number of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine is 112225-87-3.

What is the XLogP3 value of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine?

The XLogP3 value of 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine is 2.3.

How many hydrogen bond donor counts does 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine have?

1,2-Dibenzoyl-1-(T-Butyl)Hydrazine has 1 hydrogen bond donor count.

How many hydrogen bond acceptor counts does 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine have?

1,2-Dibenzoyl-1-(T-Butyl)Hydrazine has 2 hydrogen bond acceptor counts.

How many rotatable bond counts does 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine have?

1,2-Dibenzoyl-1-(T-Butyl)Hydrazine has 3 rotatable bond counts.