Nanomaterial Synthesis

Nanomaterials are any material whose size is between 1 and 100 nanometers. Synthesis methods that can precisely control the composition, structure, and function of nanomaterials are important for advances in various fields such as biomedicine. Over the last 10 years, click chemistry has emerged as a prominent and versatile approach to synthesizing various nanomaterials such as polymer nanoparticles. It provides a powerful tool for nanomaterial scientists to design the next generation of nanomaterials with targeted responses to the environment^[1].

Applications

Nanomaterials are widely used in various fields, especially biomedicine. Click chemistry provides a better choice for the synthesis of nanomaterials because of its fast reaction speed and no by-products. Sˇtorha et al^[2]. synthesized thiolated and acrylated nanoparticles from pentaerythritol tetrakis (3-mercapto-propionate) and pentaerythritol tetraacrylate using thiol-ene click reaction. These nanoparticles are mucoadhesive and can be used in the development of novel dosage forms for transmucosal drug delivery. Therefore, the synthesis of thiolated and acrylated nanoparticles by thiol-ene click reaction could be considered as a novel method for preparing mucoadhesive materials through chemical conjugation of SH-bearing moieties to water-soluble polymers.

What Can We Do?

Alfa Chemistry has a strong research foundation in the field of nanomaterial synthesis by click chemistry. We have ability to help you explore the various applications of click chemistry and provide you with related click chemistry reagents, technical advice and services. If you have problems, please don't hesitate to contact us.

References

1. Such, G.K.; et al. Synthesis and functionalization of nanoengineered materials using click chemistry. Progress in Polymer Science. 2012, 37: 985-1003.
2. Sˇtorha, A.; et al. Synthesis of thiolated and acrylated nanoparticles using thiol-ene click chemistry: towards novel mucoadhesive materials for drug delivery. RSC Advances. 2013, 33, 12275-12279.