Senecionine N-oxide

• CAS: 13268-67-2
• Catalog Number: ACM13268672
• Category: Main Products
• Molecular Weight: 351.397
• Molecular Formula: C₁₈H₂₅NO₆
• Synonyms: senecionine N-oxide;12-Hydroxysenecionan-11,16-dione 4-oxide;Senecionine oxide;Senecionin-N-oxid
• IUPAC Name: Senecionine, N-oxide
• Exact Mass: 351.16800
• Packing Group: II

Case Study

Toxicokinetic Study of Senecionine N-Oxide

Yang M, et al. Archives of toxicology, 2017, 91, 3913-3925.

The study reported evidence that pyrrolizidine alkaloid (PA) N-oxides can induce hepatic sinusoidal obstruction syndrome (HSOS) in humans. Among them, seneciopine N-oxide, as a representative PA N-oxide, was used to study its toxicokinetics by a single oral administration of seneciopine N-oxide (55 μmol/kg) to rats.
Toxicokinetics of seneciopine N-oxide
· In the group treated with senecionine N-oxide, senecionine was clearly identified as the sole detectable metabolite in the plasma. The kinetic profiles for both the administered senecionine N-oxide and its metabolite, senecionine, were similar; however, systemic exposure to senecionine was significantly lower compared to that of senecionine N-oxide, and senecionine achieved its maximum concentration much faster than senecionine N-oxide.
· Additionally, after oral administration, senecionine N-oxide gradually reached its peak plasma concentration, indicating a slower absorption rate. Following administration, senecionine N-oxide was quickly converted to senecionine, as evidenced by the notably shorter time to reach maximum concentration (Tmax) for senecionine, which then sustained elevated levels for over 11 hours.
· Pyrrole-protein adducts were transformed into senecionine, which underwent metabolic activation to produce a reactive metabolite capable of interacting with proteins to form pyrrole-protein adducts.