Reactive blue 2

• CAS: 12236-82-7
• Catalog Number: ACM12236827
• Category: Main Products
• Molecular Weight: 774.16
• Molecular Formula: C₂₉H₂₀ClN₇O₁₁S₃
• Synonyms: BASILEN BLUE E-3G;CI NO 61211;CI 61211;CIBACRON BLUE F3GA;CIBACRON BLUE 3G-A;1-AMINO-4-[[4-[[4-CHLORO-6-[[3 (OR 4)-SULFOPHENYL]AMINO]-1,3,5-TRIAZIN-2-YL]AMINO]-3-SULFOPHENYL]AMINO]-9,10-DIHYDRO-9,10-DIOXO-2-ANTHRACENESULFONIC ACID;REACTIVE BLUE 2;PROCION BLUE HB
• IUPAC Name: 1-amino-4-[4-[[4-chloro-6-(3-sulfoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfoanilino]-9,10-dioxoanthracene-2-sulfonicacid
• Canonical SMILES: C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3NC4=CC(=C(C=C4)NC5=NC(=NC(=N5)NC6=CC(=CC=C6)S(=O)(=O)O)Cl)S(=O)(=O)O)S(=O)(=O)O)N
• InChI Key: JQYMGXZJTCOARG-UHFFFAOYSA-N
• Melting Point: >300ºC
• Density: 1.845 g/cm³
• Appearance: saline suspension
• EC Number: 235-465-0
• Exact Mass: 773.00700
• Hazard Statements: Xi
• Safety Description: 26-36
• Stability: Stable. Incompatible with strong oxidizing agents.
• WGK Germany: 3

Case Study

Preparation and Evaluation of Reactive Blue 2 Modified Chitosan Adsorbent

Vasconcelos, Helder L., et al. Reactive and Functional Polymers, 2007, 67(10), 1052-1060.

Reactive blue 2 (RB2) dye was immobilized on chitosan microspheres and the adsorption performance of the adsorbent for Cu(II) and Ni(II) ions from aqueous solutions was evaluated. The results showed that the maximum adsorption of Cu(II) and Ni(II) ions by CHS-RB2 adsorbent was 0.90 mmol g -1 and 0.19 mmol g -1, respectively.
Preparation procedure of CHS-RB2 adsorbent
· Chitosan solution was prepared by dissolving 3.00 g of chitosan powder in 100 ml of a 5% (v/v) acetic acid solution. Once fully mixed, chitosan microspheres were created by feeding the chitosan solution through a peristaltic pump. The solution was pushed through a 2.0 mm inner diameter nozzle using compressed air, dropped into a bath containing a 2.0 mol/L NaOH solution, and then gelled microspheres were washed in distilled water until reaching a neutral pH and finally dried in an oven at 60 °C.
· To conduct the experiment, 5.0 g of chitosan microspheres were exposed to a 3.0% (w/v) RB2 solution (10 ml) and 1.0 mol/L NaCl (60 ml). After 1 h of waiting for equilibrium, 3.2 mol/L1 Na2CO3 (30 ml) were introduced into the system and maintained at 80°C for 7 h in a sealed flask with stirring. Following the reaction time, the microspheres were washed multiple times with distilled water, 2.0 mol/L NaCl, and 10% methanol.

Constitutional Isomers of the P2 Receptor Antagonist Reactive Blue 2

Glänzel, Markus, et al. European journal of medicinal chemistry, 2003, 38(3), 303-312.

Reactive blue 2 (RB 2), an anthraquinone derivative, is among the most commonly utilized P2 receptor antagonists. This work evaluated the P2Y selectivity of two structural isomers of RB 2, including the meta- and para-isomers. The results showed that neither the RB 2 mixture nor the pure ortho- and meta-isomers were P2Y1-like- versus P2X1-selective antagonists. In contrast, the pure para-isomer of RB 2 was a moderate P2Y1-like- versus P2X1-selective antagonist.
Experimental methods and results
· The commercial RB 2 sample was determined to be a mixture of 35% meta- and 65% para-constitutional isomers of the terminal ring F.
· The two constitutional isomers of RB 2 were synthesized and tested alongside the ortho isomer Cibacron Blue 3GA (CB 3GA) on contractions of the rat vas deferens (RVD) stimulated by α,β-methylene ATP (α,β-MeATP) through P2X1-receptors, and relaxations of the carbachol-precontracted guinea pig taenia coli induced by adenosine 5'-O-(2-thiophosphate) (ADPβS) through P2Y1-like-receptors.
· The compounds all showed inhibition of the α,β-MeATP-induced contraction of the RVD and the ADPβS-induced relaxation of the carbachol-precontracted guinea pig taenia coli.
· The IC50 values at P2X1-R were 9.1 μM for CB 3GA, 28.4 μM for RB 2, 19.7 μM for RB 2 meta, and 35.5 μM for RB 2 para. The IC50 values at P2Y1-like-R were 17.4 μM for CB 3GA, 7.7 μM for RB 2, 12.0 μM for RB 2 meta, and 2.6 μM for RB 2 para.

Custom Q&A

What is the molecular formula of Reactive Blue 2?

The molecular formula of Reactive Blue 2 is C29H20ClN7O11S3.

What are some synonyms of Reactive Blue 2?

Some synonyms of Reactive Blue 2 are Affi gel blue, Cibacron Blue 3G, Cibacronblau F3G-A, and CHEBI:34946.

What is the molecular weight of Reactive Blue 2?

The molecular weight of Reactive Blue 2 is 774.2 g/mol.

When was Reactive Blue 2 created?

Reactive Blue 2 was created on June 24, 2005.

What is the description of Reactive Blue 2?

Reactive Blue 2 is an anthraquinone.

What is the IUPAC name of Reactive Blue 2?

The IUPAC name of Reactive Blue 2 is 1-amino-4-[4-[[4-chloro-6-(3-sulfoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfoanilino]-9,10-dioxoanthracene-2-sulfonic acid.

What is the InChI of Reactive Blue 2?

The InChI of Reactive Blue 2 is InChI=1S/C29H20ClN7O11S3/c30-27-35-28(33-13-4-3-5-15(10-13)49(40,41)42)37-29(36-27)34-18-9-8-14(11-20(18)50(43,44)45)32-19-12-21(51(46,47)48)24(31)23-22(19)25(38)16-6-1-2-7-17(16)26(23)39/h1-12,32H,31H2,(H,40,41,42)(H,43,44,45)(H,46,47,48)(H2,33,34,35,36,37).

What is the InChIKey of Reactive Blue 2?

The InChIKey of Reactive Blue 2 is JQYMGXZJTCOARG-UHFFFAOYSA-N.

What is the CAS number of Reactive Blue 2?

The CAS number of Reactive Blue 2 is 12236-82-7.

What is the XLogP3-AA value of Reactive Blue 2?

The XLogP3-AA value of Reactive Blue 2 is 4.4.