ZM323881 HCl

• CAS: 193000-39-4
• Catalog Number: ACM193000394
• Category: Inhibitors
• Molecular Weight: 411.12
• Molecular Formula: C22H19ClFN3O2
• Description: ZM323881 is a potent and selective inhibitor of VEGF-R2 tyrosine kinase in vitro (IC(50) < 2 nM), compared with other receptor tyrosine kinases, including VEGF-R1 (IC(50) > 50 microM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation (IC(50) = 8 nM) and VEGF-R2 tyrosine phosphorylation in vitro.
• Synonyms: ZM323881; ZM 323881; ZM-323881; ZM323881 HCl; ZM323881 hydrochloride
• IUPAC Name: 5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride
• Canonical SMILES: OC1=CC(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)=C(F)C=C1C.[H]Cl
• InChI: InChI=1S/C22H18FN3O2.ClH/c1-14-9-18(23)20(11-21(14)27)26-22-17-8-7-16(10-19(17)24-13-25-22)28-12-15-5-3-2-4-6-15;/h2-11,13,27H,12H2,1H3,(H,24,25,26);1H
• InChI Key: AVRHWGLIYGJSOD-UHFFFAOYSA-N
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid powder
• Shelf Life: >5 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 324077-30-7 (free base); 193000-39-4 (HCl)
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 64.16; H, 4.65; Cl, 8.61; F, 4.61; N, 10.20; O, 7.77
• Exact Mass: 375.13831
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).