VY-3-135

• CAS: 1824637-41-3
• Catalog Number: ACM1824637413
• Category: Inhibitors
• Molecular Weight: 429.52
• Molecular Formula: C26H27N3O3
• Description: VY-3-135 is a potent ACSS2 inhibitor. VY-3-135 acts as a transition-state mimetic to block ACSS2 activity in vitro and in vivo. Pharmacologic inhibition of ACSS2 as a single agent impaired breast tumor growth. The aqueous solubility of VY-3-135 was 21.7 μM. The aqueous solubility of VY-3-135 was 21.7 μM. VY-3-135 is a potent low nanomolar inhibitor of ACSS2 in cancer cells in vitro. VY-3-135 potently inhibits ACSS2 dependent fatty acid metabolism but has no effect on gene expression in tumors.
• Synonyms: VY-3-135; VY3-135; VY 3-135; VY-3135; VY3135; VY 3135
• IUPAC Name: (R)-1-Ethyl-2-(hydroxydiphenylmethyl)-N-(2-hydroxypropyl)-1H-benzo[d]imidazole-6-carboxamide
• Canonical SMILES: O=C(C1=CC=C2C(N(CC)C(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)=N2)=C1)NC[C@H](O)C
• InChI: InChI=1S/C26H27N3O3/c1-3-29-23-16-19(24(31)27-17-18(2)30)14-15-22(23)28-25(29)26(32,20-10-6-4-7-11-20)21-12-8-5-9-13-21/h4-16,18,30,32H,3,17H2,1-2H3,(H,27,31)/t18-/m1/s1
• InChI Key: KTPYOTKTDCLZHR-GOSISDBHSA-N
• Solubility: To be determined
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: To be determined
• Elemental Analysis: C, 72.71; H, 6.34; N, 9.78; O, 11.17
• Exact Mass: 429.2052
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).