Tunicamycin

• CAS: 11089-65-9
• Catalog Number: ACM11089659
• Category: Inhibitors
• Molecular Weight: 816.89
• Molecular Formula: C₃₇H₆₀N₄O₁₆
• Description: Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity.Tunicamycin increases exosome release in cervical cancer cells.
• Synonyms: tunicamycin, Tunicamycin A1, CID5607, 11089-65-9
• IUPAC Name: N-[2-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[2-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl]-4,5-dihydroxyoxan-3-yl]-12-methyltridec-2-enamide
• Canonical SMILES: CC(C)CCCCCCCCC=CC(=O)NC1C(C(C(OC1OC2C(C(C(C(O2)CO)O)O)NC(=O)C)CC(C3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O)O)O
• InChI Key: YJQCOFNZVFGCAF-UHFFFAOYSA-N
• Melting Point: 234 - 235ºC
• Density: 1.57g/cm³
• Appearance: White to off-white powder
• Storage: Powder-20°C, 3 years; In solvent-80°C. 6 months; -20°C, 1 month.
• Exact Mass: 816.40000
• Hazard Statements: T+: Very toxic
• H-Bond Acceptor: 16
• H-Bond Donor: 11
• Packing Group: II
• Safety Description: 28-37/39-45
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: Streptomyces lysosuperficus