Spliceostatin A

• CAS: 391611-36-2
• Catalog Number: ACM391611362
• Category: Inhibitors
• Molecular Weight: 521.65
• Molecular Formula: C28H43NO8
• Description: Spliceostatin A is a potent splicing inhibitor. Spliceostatin A (SSA) causes cell cycle arrest at G1 and G2/M phases. Spliceostatin A treatment inhibits mitotic clonal expansion and adipogenesis. Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation. Spliceostatin A binds to the SF3B subcomplex of the U2 small nuclear ribonucleoprotein particle (snRNP), limits U1 snRNP availability in splicing, resulting in premature cleavage and polyadenylation of MALAT1, a nuclear lncRNA, as well as protein-coding mRNAs. Therefore, truncated transcripts are exported into the cytoplasm and translated, resulting in aberrant protein products.
• IUPAC Name: (2Z,4S)-4-(Acetyloxy)-N-[(2R,3R,5S,6S)-tetrahydro-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4-hydroxy-7-methoxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]-2,5-dimethyl-2H-pyran-3-yl]-2-pentenamide
• Canonical SMILES: C[C@H](OC(C)=O)/C=C\C(N[C@H]1[C@@H](C)O[C@@H](C/C=C(C)/C=C/[C@@H](O[C@](C)(OC)C2)[C@@H](O)[C@@]32CO3)[C@@H](C)C1)=O
• InChI: InChI=1S/C28H43NO8/c1-17(9-12-24-26(32)28(16-34-28)15-27(6,33-7)37-24)8-11-23-18(2)14-22(20(4)36-23)29-25(31)13-10-19(3)35-21(5)30/h8-10,12-13,18-20,22-24,26,32H,11,14-16H2,1-7H3,(H,29,31)/b12-9+,13-10-,17-8+/t18-,19-,20+,22+,23-,24+,26+,27-,28+/m0/s1
• InChI Key: XKSGIJNRMWHQIQ-CGPJBNNXSA-N
• Solubility: To be determined
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: To be determined
• Elemental Analysis: C, 64.47; H, 8.31; N, 2.69; O, 24.54
• Exact Mass: 521.2989
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).