Span 60

• CAS: 1338-41-6
• Catalog Number: ACM1338416-3
• Category: Non-ionic Surfactants
• Molecular Weight: 430.62
• Molecular Formula: C24H46O6
• Description: Sorbitan monostearate is an ester of sorbitan (a sorbitol derivative) and stearic acid and is sometimes referred to as a synthetic wax. It is primarily used as an emulsifier to keep water and oils mixed. Sorbitan monostearate is a non-ionic surfactant with emulsifying, dispersing, and wetting properties.
• Synonyms: Arlacel 60
• IUPAC Name: [2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] octadecanoate
• Canonical SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC(C1C(C(CO1)O)O)O
• InChI: InChI=1S/C24H46O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h20-21,23-26,28H,2-19H2,1H3/t20-,21?,23+,24-/m1/s1
• InChI Key: HVUMOYIDDBPOLL-IIZJTUPISA-N
• Boiling Point: 579.0±45.0 °C at 760 mmHg
• Melting Point: 52-54 °C
• Flash Point: >230 °F
• Density: 1.1±0.1 g/mL
• Solubility: Practically insoluble, but dispersible in water, slightly soluble in alcohol.
• Appearance: White to light yellow powder
• Application: Sorbitan monooctadecanoate can be used as an excipient, such as emulsifiers, nonionic surfactants, solubilizers, as well as wetting and dispersing/suspending agents.
• Storage: Store at 2-8 ℃
• Complexity: 417
• EC Number: 215-664-9
• Exact Mass: 430.32943918
• Formal Charge: 0
• Hazard Codes: Xi
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Isomeric SMILES: CCCCCCCCCCCCCCCCCC(=O)OC[C@H]([C@@H]1[C@@H]([C@H](CO1)O)O)O
• MDL Number: MFCD00005366
• Monoisotopic Mass: 430.32943918
• PSA: 96.22
• Refractive Index: 1.496
• Rotatable Bond Count: 20
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
• Topological Polar Surface Area: 96.2 Å2
• Vapor Pressure: 0.0±3.6 mmHg at 25°C
• WGK Germany: 1
• XLogP3: 7.13
• XLogP3-AA: 6.9

Case Study

Span 60/Tween 60 Niosomes as Vehicle for α-Tocopherol Delivery

Basiri L, et al. Lwt, 2017, 84: 471-478.

Niosomes, as vehicles for α-Tocopherol were formulated applying film hydration method to improve the availability and stability of α-Toc. α-Toc is believed to bind with the hydrophobic section of surfactants. The smaller head groups and longer alkyl chain in the structure of surfactant are, the bigger vesicle they result in.
Preparation of Span 60/Tween 60 niosomes
· The appropriate amount of wall material dissolved in 10 mL of ethanol:chloroform mixture at volume ratio of 1:2.
· The hydration medium was phosphate buffered saline (PBS, pH 7.4).
· The vesicle suspension was sonicated using a probe sonicator, in 4 cycles of 180 s "on" and 60 s "off", leading to the formation of unilamellar vesicles of niosomes.

Preparation of New Ibuprofen-Span 60 Microspheres

Mady, Omar. Journal of Surfactants and Detergents, 2017, 20, 219-232.

Span 60 surfactant-Ibuprofen microspheres can be prepared by two technologies, namely solvent evaporation technology and melt dispersion technology.
· Preparation of Span 60 Microspheres by Solvent Evaporation Technique
The aqueous solution was 100 ml of 0.1 N HCl containing different concentrations of PVP (1, 2 or 3%) as an anti-aggregating agent. The organic phase was composed of a fixed volume of dichloromethane (50 ml) containing the required weight of Ibuprofen and Span 60 (3:1, 1:1 and 1:3) drug:Span ratios. The prepared homogeneous organic phase was poured onto the stirred aqueous phase at a constant stirring rate. The system was continuously stirred until complete evaporation of the dichloromethane. The microcapsules were collected by filtration and air dried.
· Preparation of Span 60 microspheres by Melt Dispersion Technique
The aqueous solution of 100 ml of 0.1 N HCl containing different concentrations of PVP as an antiaggregating agent was heated over the melting point of Span 60. The organic phase of the required weight of Ibuprofen and Span 60 (3:1, 1:1 and 1:3) drug:Span ratios, was melted and added to preheated aqueous phase while stirring. The system was continuously stirred until the room temperature was achieved. The microspheres were collected by filtration and air-dried.

Preparation of New Peceol/Span 60 Niosomal Formulations

AbuElfadl, Aya, et al. International Journal of Nanomedicine, 2021, 5581-5601.

Span 60 serves as a bioenhancer for the preparation of new candesartan cilexetil (CC)-loaded liposomes. The niosomal formulations were prepared using the conventional thin film hydration method.
Preparation of niosomal formulations
· 300 micromoles of a surfactant mixture (Span 60 and Peceol) as well as CHOL were dissolved in 6 mL of chloroform. The specific amount of drug was dissolved in 3 mL of methanol. The two solutions were mixed in a closed tube with a ratio of chloroform to methanol of 2:1 v/v, based on a preliminary trial.
· The mixture was then sonicated in an ultrasonic bath for 10 minutes. Next, the resulting mixture was transferred to a 500 mL round bottom flask and evaporated using a rotary evaporator at 100 rpm under reduced pressure at 60°C, until a dry thin film formed on the inner wall of the flask. The flask was left in a desiccator overnight to ensure the removal of any excess organic solvent.
· Following this, the film was hydrated with 10 mL of deionized water at 60°C for one hour while rotating at 150 rpm, until a milky niosomal dispersion was formed. The dispersion was further sonicated in an ultrasonic bath for 10 minutes at 25°C to ensure the homogenization of niosome size, and then refrigerated overnight at 4°C.

Custom Q&A

What is the molecular formula of Span 60?

The molecular formula of Span 60 is C24H46O6.

What are some synonyms for Span 60?

Some synonyms for Span 60 are Sorbitan Monostearate, Arlacel 60, and Sorgen 50.

What is the molecular weight of Span 60?

The molecular weight of Span 60 is 430.6 g/mol.

What is the IUPAC name of Span 60?

The IUPAC name of Span 60 is [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] octadecanoate.

What is the InChI key of Span 60?

The InChI key of Span 60 is HVUMOYIDDBPOLL-XWVZOOPGSA-N.

What is the Canonical SMILES of Span 60?

The Canonical SMILES of Span 60 is CCCCCCCCCCCCCCCCCC(=O)OCC(C1C(C(CO1)O)O)O.

What is the XLogP3-AA value of Span 60?

The XLogP3-AA value of Span 60 is 6.9.

How many hydrogen bond donor counts does Span 60 have?

Span 60 has 3 hydrogen bond donor counts.

How many hydrogen bond acceptor counts does Span 60 have?

Span 60 has 6 hydrogen bond acceptor counts.

Is Span 60 a canonicalized compound?

Yes, Span 60 is a canonicalized compound.