Sodium picosulfate

• CAS: 10040-45-6
• Catalog Number: ACM10040456
• Category: Main Products
• Molecular Weight: 481.41
• Molecular Formula: C₁₈H₁₃NNa₂O₈S₂
• Synonyms: disodium,[4-[pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] sulfate
• IUPAC Name: Picosulfate Sodium
• Melting Point: 272 - 275ºC
• Appearance: white crystalline powder
• Exact Mass: 480.98800

Case Study

Sodium Picosulfate with Magnesium Citrate (SPMC) as Bowel Prep for Colonoscopy

Kim, Hyun Gun, et al. Gut and liver, 2015, 9(4), 494.

Colonoscopy is considered the most effective screening procedure for colorectal cancer. Polyethylene glycol (PEG) is widely accepted as a standard bowel preparation regimen, but its unpleasant taste and high intake lead to low compliance rates and poor cleaning quality. Sodium picosulfate with magnesium citrate (SPMC) has emerged as a low-volume, dual-action bowel cleanser. The study investigated the cleaning efficacy, safety, and tolerability of SPMC compared with traditional PEG formulations. Results suggested that SPMC is a good alternative to traditional high-volume PEG for intestinal preparation.
Trial Design
· The study was a multicenter, randomized, single-blind, non-inferiority trial conducted in 13 institutions in Korea and involved participants aged 20 to 75 undergoing selective outpatient colonoscopy.
· Exclusion criteria included a history of prior colorectal surgery, intestinal obstruction, severe constipation, inflammatory bowel disease, pregnancy, cognitive impairment, and renal impairment.
· Patients were allocated to receive either split-dose SPMC with bisacodyl or split-dose PEG using randomization tables generated by an independent biostatistician.

Custom Reviews

August 15, 2023

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High purity API
The platform provides sodium picosulfate have a few impurities, and it is easy to purify and prepare drugs.

Custom Q&A

What's EC number of sodium picosulfate?

233-120-9

What is the form of sodium picosulfate ?

White to off-white powder

What category of chemical reagent does sodium picosulfate belong to?

Small molecule inhibitors

What is the molecular structure of sodium picosulfate ?

C18H13NO8S2.2Na

What is the InChIKey of sodium picosulfate?

GOZDTZWAMGHLDY-UHFFFAOYSA-L

What is the molecular mass of sodium picosulfate?

481.41

What are the storage conditions for sodium picosulfate?

Sodium picosulfate should be stored in a dark place at room temperature filled with inert gas

How soluble is sodium picosulfate?

Sodium picosulfate is soluble in water and slightly soluble in 96% ethanol.

What are the pharmacologic effects of sodium picosulfate?

Pharmacology shows that Sodium Picolinate acts in the colon, and is hydrolyzed by enzymes produced by colonic flora to produce the active ingredient of Chemicalbook, diphenols, which can directly stimulate the intestinal mucosa, promote intestinal peristalsis and inhibit the absorption of water in the intestinal tract, and show the effect of inducing diarrhea. Urinary excretion shows that there is almost no absorption of sodium picosulfate in the gastrointestinal tract, the systemic effect is very little, and the efficacy is not related to the plasma concentration of the active ingredient.

What is the customs code for sodium picosulfate?

2933399090