SM-102

• CAS: 2089251-47-6
• Catalog Number: ACM2089251476-3
• Category: Others
• Molecular Weight: 710.18
• Molecular Formula: C44H87NO5
• Description: SM-102 is an ionizable amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles. Administration of luciferase mRNA in SM-102-containing lipid nanoparticles induces hepatic luciferase expression in mice. Formulations containing SM-102 have been used in the development of lipid nanoparticles for delivery of mRNA-based vaccines.
• Synonyms: SM-102; SM102; SM 102
• IUPAC Name: heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate
• Canonical SMILES: OCCN(CCCCCC(OCCCCCCCCCCC)=O)CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O
• InChI: InChI=1S/C44H87NO5/c1-4-7-10-13-16-17-18-24-32-41-49-43(47)35-29-25-31-38-45(39-40-46)37-30-23-19-22-28-36-44(48)50-42(33-26-20-14-11-8-5-2)34-27-21-15-12-9-6-3/h42,46H,4-41H2,1-3H3
• InChI Key: BGNVBNJYBVCBJH-UHFFFAOYSA-N
• Solubility: To be determined
• Appearance: Oily liquid
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: Ionizable amino lipid that can be used for the formation of lipid nanoparticles (LNPs).
• Drug Formulation: To be determined
• Elemental Analysis: C, 74.42; H, 12.35; N, 1.97; O, 11.26
• Exact Mass: 709.6584
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: 1. In MA-10 Leydig cells, the IK(erg) was also blocked by the presence of SM-102 or TurboFectin. The IC50 value for SM-102-induced inhibition of IK(erg) in MA-10 cells was 98 μM. In BV2 microglial cells, the amplitude of the inwardly rectifying K+ current was inhibited by SM-102. Taken together, the presence of SM-102 concentration-dependently inhibited IK(erg) in endocrine cells (e.g., GH3 or MA-10 cells), and such action may contribute to their functional activities, assuming that similar in vivo findings exist.; Reference: Biomedicines. 2021 Oct 1;9(10):1367. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533363/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).