Selamectin

• CAS: 220119-17-5
• Catalog Number: ACM220119175
• Category: Inhibitors
• Molecular Weight: 769.967
• Molecular Formula: C₄₃H₆₃NO₁₁
• Description: Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC50 of 120 nM.
• Synonyms: Selamectin;hypnocarpic acid;AverMectin A1a,25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-Methyl-a-L-arabino-hexopyranosyl)-5-deMethoxy-25-de(1-Methylpropyl)-22,23-dihydro-5-(hydroxyiMino)-,(5Z)-;(5Z)-25-Cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-avermectin A1a;Revolution (antibiotic);Stronghold
• Canonical SMILES: O[C@@]12[C@@]3([H])/C(C(C)=C[C@@]1([H])C(O[C@]4([H])C[C@]5(O[C@@](C/C=C(C)/[C@@H](O[C@@]6([H])C[C@@H]([C@@H](O)[C@H](C)O6)OC)[C@@H](C)/C=C/C=C2\CO3)([H])C4)O[C@H](C7CCCCC7)[C@@H](C)CC5)=O)=N\O
• Appearance: Solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Supplemental Hazard Statements: H413

Custom Q&A

What is the molecular formula of selamectin?

The molecular formula of selamectin is C43H63NO11.

What is the molecular weight of selamectin?

The molecular weight of selamectin is 770.0 g/mol.

What is the IUPAC name of selamectin?

The IUPAC name of selamectin is (1R,4S,5'S,6R,6'S,8R,10E,12S,13S,14E,16E,20R,21Z,24S)-6'-cyclohexyl-24-hydroxy-21-hydroxyimino-12-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.1 4,8 .0 20,24 ]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one.

What is the InChI of selamectin?

The InChI of selamectin is InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1.

What is the InChIKey of selamectin?

The InChIKey of selamectin is AFJYYKSVHJGXSN-XHKIUTQPSA-N.

What are some synonyms of selamectin?

Some synonyms of selamectin are Revolution, 220119-17-5, UK-124,114, and UK-124114.

What is the EC number of selamectin?

The European Community (EC) number of selamectin is 815-979-7.

What is the ChEMBL ID of selamectin?

The ChEMBL ID of selamectin is CHEMBL1908325.

What are the different types of parasitic infections that selamectin can be used to treat in dogs and cats?

Selamectin can be used to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, ticks, hookworms, roundworms, and lungworms in dogs and cats.

Is selamectin approved for human use?

No, selamectin is not approved for human use.