S-(3-Carboxypropyl)-L-cysteine

• CAS: 30845-11-5
• Catalog Number: ACM30845115
• Category: Others
• Molecular Weight: 207.24
• Molecular Formula: C7H13NO4S
• Description: S-(3-Carboxypropyl)-L-cysteine is a thioether derivative of L-cysteine.
• IUPAC Name: (R)-4-[(2-Amino-2-carboxyethyl)thio]butanoic Acid
• Canonical SMILES: O=C(O)CCCSC[C@H](N)C(O)=O
• InChI: InChI=1S/C7H13NO4S/c8-5(7(11)12)4-13-3-1-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)/t5-/m0/s1
• InChI Key: WNFNRNDFHINZLV-YFKPBYRVSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >3 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: S-(3-Carboxypropyl)-L-cysteine is a thioether derivative of L-cysteine.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 40.57; H, 6.32; N, 6.76; O, 30.88; S, 15.47
• Exact Mass: 207.0565
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: CPC was a competitive inhibitor with respect to both cystathionine and cysteine in the canonical and H2S synthesis reactions, respectively. The lower Ki value in the cystathionine (50 ± 3 μm) versus cysteine (180 ± 15 μm) cleavage assay suggests that CPC competes more effectively against the longer cystathionine versus the shorter cysteine substrate. The Kd(app) for CPC binding to CSE was 26 ± 3 μm. In cell culture, CPC inhibited the transsulfuration flux, an indicator of the canonical CSE reaction; ≥80% inhibition was observed in HepG2 cells at a concentration of 2.5 mm CPC (Fig. 5A).; Reference: J Biol Chem. 2019 Jul 12;294(28):11011-11022. https://pubmed.ncbi.nlm.nih.gov/31160338/
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).