Roquinimex

• CAS: 84088-42-6
• Catalog Number: ACM84088426
• Category: Inhibitors
• Molecular Weight: 308.33
• Molecular Formula: C₁₈H₁₆N₂O₃
• Description: Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.IC50 value:Target: TNF alphaProphylactic administration of DSS-treated mice with roquinimex significantly reduced clinical signs of colitis, MDS and the CH-reduction. Moreover, in roquinimex treated animals, the MPO activity was significantly reduced by more than 50% compared to DSS control mice. Notably, therapeutic administration of roquinimex in DSS-treated mice also significantly inhibited the MDS, CH-reduction and MPO activity . Linomide, a synthetic immunomodulator, at concentrations effective in vivo reduces the number of MBP-reactive TNF-alpha and increases MBP-reactive IL-10 and TGF-beta mRNA expressing MNC from MS patients' blood when analysed in vitro. Compared to dexamethasone, Linomide up-regulated levels of blood MNC expressing mRNA of TGF-beta after culture in presence of MBP .
• Synonyms: N-PHENYLMETHYL-1,2-DIHYDRO-4-HYDROXYL-N,1-DIMETHYL-2-OXO-QUINOLINE-3-CARBOXAMIDE;ROQUINIMEX;LINOMIDE;LS-2616;1,2-DIHYDRO-4-HYDROXY-N,1-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE;1,2-DIHYDRO-4-HYDROXY-N,N-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE;4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide;1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
• Canonical SMILES: O=C(C1=C(O)C2=C(N(C)C1=O)C=CC=C2)N(C)C3=CC=CC=C3
• Appearance: solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Hazard Statements: Xn
• Safety Description: 36/37
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Supplemental Hazard Statements: H302
• Symbol: GHS07

Custom Q&A

What is the chemical formula of roquinimex?

The chemical formula of roquinimex is C18H16N2O3.

What is the molecular weight of roquinimex?

The molecular weight of roquinimex is 308.3 g/mol.

What is the IUPAC name of roquinimex?

The IUPAC name of roquinimex is 4-hydroxy-N,1-dimethyl-2-oxo-N-phenylquinoline-3-carboxamide.

What are the synonyms for roquinimex?

Some synonyms for roquinimex include Linomide, 84088-42-6, and LS-2616.

What are the effects of roquinimex?

Roquinimex is suggested to increase the activity of NK cells and macrophage cytotoxicity, inhibit angiogenesis, and decrease the synthesis of TNF alpha.

What is the CAS number of roquinimex?

The CAS number of roquinimex is 84088-42-6.

What is the European Community (EC) number of roquinimex?

The European Community (EC) number of roquinimex is 635-913-9.

What is the InChIKey of roquinimex?

The InChIKey of roquinimex is SGOOQMRIPALTEL-UHFFFAOYSA-N.

What is the XLogP3-AA value of roquinimex?

The XLogP3-AA value of roquinimex is 2.7.

What is the topological polar surface area of roquinimex?

The topological polar surface area of roquinimex is 60.