Ritonavir

• CAS: 155213-67-5
• Catalog Number: ACM155213675
• Category: Inhibitors
• Molecular Weight: 720.94
• Molecular Formula: C37H48N6O5S2
• Description: Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.
• Synonyms: Thiazol-5-ylmethyl ((2S,3S,5S)-3-hydroxy-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl)carbamate
• IUPAC Name: 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
• Canonical SMILES: CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C[C@@H]([C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
• InChI: InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
• InChI Key: NCDNCNXCDXHOMX-XGKFQTDJSA-N
• Melting Point: 122-127 °C
• Appearance: White to almost white powder to crystaline
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• HS Code: 2942000000
• LogP: 7.07790
• PSA: 22.26
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Specific Rotation: 8° (C=2,MeOH)

Custom Q&A

What is the molecular formula of ritonavir?

The molecular formula of ritonavir is C37H48N6O5S2.

What is the molecular weight of ritonavir?

The molecular weight of ritonavir is 720.9 g/mol.

When was ritonavir first created and modified?

Ritonavir was first created on March 26, 2005, and last modified on December 30, 2023.

What are some synonyms for ritonavir?

Some synonyms for ritonavir include Norvir, ABT-538, and Abbott 84538.

What is the main role of ritonavir in the treatment of HIV infection?

Ritonavir is used as a pharmacokinetic enhancer to boost the activity of other HIV medicines in the treatment of HIV infection.

How does ritonavir function as a booster for other protease inhibitors?

Ritonavir is a potent CYP3A inhibitor that increases peak and trough plasma drug concentrations of other protease inhibitors, enhancing their overall efficacy.

In what type of combination therapy is ritonavir commonly used for the treatment of HCV infections?

Ritonavir is commonly used in combination therapies for the treatment of HCV infections as a booster for other protease inhibitors.

What are some FDA-approved products that contain ritonavir for the treatment of HCV infections?

FDA-approved products that contain ritonavir for the treatment of HCV infections include Viekira Pak and Technivie.

Which guidelines recommend ritonavir-boosted combination therapies as first-line therapy for HCV Genotype 1a/b and 4 treatment-naïve patients?

The American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) guidelines recommend ritonavir-boosted combination therapies as first-line therapy for HCV Genotype 1a/b and 4 treatment-naïve patients.

What is the commercial name of the Health Canada-approved fixed-dose combination product that contains ritonavir for the treatment of HCV infections?

The Health Canada-approved fixed-dose combination product that contains ritonavir for the treatment of HCV infections is called Holkira Pak.