Proguanil hydrochloride

• CAS: 637-32-1
• Catalog Number: ACM637321
• Category: Solvents
• Molecular Weight: 290.19
• Molecular Formula: C11H17Cl2N5
• Description: Proguanil hydrochloride, an antimalarial prodrug, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor.
• Synonyms: Chlorguanide, N¹-(4-Chlorophenyl)-N⁵-isopropylbiguanide, Proguanil hydrochloride
• IUPAC Name: hydrogen 1-({amino[(4-chlorophenyl)amino]methylidene}amino)-N'-(propan-2-yl)methanimidamide chloride
• Canonical SMILES: [H+].[Cl-].CC(C)N=C(N)N=C(N)NC1=CC=C(Cl)C=C1
• InChI: 1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
• InChI Key: SARMGXPVOFNNNG-UHFFFAOYSA-N
• Boiling Point: 402.7ºC at 760 mmHg
• Melting Point: 249-251ºC
• Flash Point: 197.4ºC
• Solubility: acetonitrile: water: ~1mg/mL
• Application: Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.
• Color: White to off-white
• EC Number: 211-283-7
• Exact Mass: 289.08609
• Form: Crystalline powder
• LogP: 4.0653
• MDL Number: MFCD01732193
• NACRES: NA.77
• PSA: 83.79
• PubChem ID: 329799959
• Storage Conditions: -20°C Freezer