Poly-L-lysine hydrobromide

• CAS: 25988-63-0
• Catalog Number: ACM25988630-7
• Category: Main Products
• Molecular Weight: 402.5g/mol
• Molecular Formula: C18H38N6O4
• Synonyms: L-Lys-(L-Lys)n-L-Lys.xHBr
• IUPAC Name: (2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]hexanoyl]amino]hexanoic acid
• Canonical SMILES: C(CCN)CC(C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N
• InChI: InChI=1S/C18H38N6O4/c19-10-4-1-7-13(22)16(25)23-14(8-2-5-11-20)17(26)24-15(18(27)28)9-3-6-12-21/h13-15H,1-12,19-22H2,(H,23,25)(H,24,26)(H,27,28)/t13-,14-,15-/m0/s1
• InChI Key: WBSCNDJQPKSPII-KKUMJFAQSA-N
• Complexity: 463
• Covalently-Bonded Unit Count: 1
• Exact Mass: 402.295454g/mol
• Formal Charge: 0
• H-Bond Acceptor: 8
• H-Bond Donor: 7
• Heavy Atom Count: 28
• Monoisotopic Mass: 402.295454g/mol
• Rotatable Bond Count: 17
• UNII: Y7F82M80K8
• XLogP3: -5.6

Case Study

Structural study of poly-L-lysine hydrobromide

Okubo, Tsuneo, Junichi Okamoto, and Akira Tsuchida. Colloid and Polymer Science 288 (2010): 981-989.

The aqueous solution patterns of poly-lysine hydrobromide and its low molecular weight analogs were studied. Several important results were obtained. First, the morphology of the dried crystals changes with the distance from the center of the dried film, which is a typical feature of dissipative crystallization found so far. Second, the morphology of the isomers and isomers of the polymer and analogs is very similar to each other. The size of the broad ring is also not related to stereospecificity. Third, the formation of a stereo complex between poly-lysine and poly-lysine is unreasonable.
The concentration of poly-β-lysine hydrobromide and poly-β-lysine hydrobromide stock solutions is 0.01 monoM. The water used for sample preparation is purified by a reagent grade system. An aliquot (0.1 ml) of the sample solution is carefully and gently placed on a plastic dish. The coverslip can be used without further rinsing. 4 ml of the solution is placed on a watch glass. 5 ml of the solution is placed in a medium glass dish. The suspension is placed into the matrix using a disposable serological pipette. The pattern of the solution during the drying process is observed on a table covered with a black plastic cloth. The room temperature is adjusted at 24℃. The humidity in the room was not regulated and was between 47% and 58%. Macroscopic patterns were observed on a digital camera equipped with a macro lens plus a life-size converter EF or a zoom lens. On coverslips and glass dishes or watch glasses, respectively. Microscopic drying patterns were observed with a microscope. The thickness profile of the dried film on the coverslip was measured using a laser 3D profilometer.

Poly-l-lysine hydrobromide in Monolayers on Silica

Kosior, Dominik, et al. The Journal of Physical Chemistry C 124.8 (2020): 4571-4581.

The adsorption kinetics of poly-L-lysine (PLL) with different ionic strengths on silica were determined in situ under controlled flow conditions using optical reflectometry and streaming potential methods. The precise measurement of the initial adsorption rate allowed us to determine the mass transfer rate constant, which was fully explained based on the convection-diffusion theory. The kinetic run also confirmed the irreversible adsorption mechanism of PLL on silica. These experimental results were quantitatively interpreted based on theoretical data derived from a random sequential adsorption model based on the coarse-grained Monte Carlo method. A significant improvement of our approach compared to previous literature reports is the consideration of physicochemical parameters characterizing PLL molecules, especially their shape and size.
A stock solution was prepared by dissolving an appropriate amount of poly-l-lysine hydrobromide in NaCl solution. The investigated solid surface was cleaned in a 1:1 mixture of H2SO4 and H2O for 30 min, then rinsed with water and then immersed in 80°C water for 30 min. Finally, the surface was dried in a nitrogen flow in an air plasma chamber for 30 min. The exact thickness of the silicon dioxide layer was determined by zero ellipsometry in air. The data were analyzed using a slab model, where the refractive indices of silicon and silicon dioxide at 633 nm were fixed to 3.85 + 0.02i and 1.457, respectively.