Osthole

• CAS: 484-12-8
• Catalog Number: ACM484128
• Category: Inhibitors
• Molecular Weight: 244.29
• Molecular Formula: C15H16O3
• Description: Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.
• Synonyms: 7-Methoxy-8-(3-methyl-2-butenyl)-coumarin
• IUPAC Name: 7-Methoxy-8-(3-methylbut-2-enyl)chromen-2-one
• Canonical SMILES: CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C
• InChI: InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
• InChI Key: MBRLOUHOWLUMFF-UHFFFAOYSA-N
• Boiling Point: 347.2 °C
• Melting Point: 83-84 °C
• Density: 1.126 g/ml
• Appearance: Powder
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: Plantsother families

Synthetic Use

Downstream Synthesis Route 1

• 484-12-8

• 2221-66-1

Reference: [1]Molecules,2000,vol. 5,p. 880 - 885
[2]Chemische Berichte,1942,vol. 75,p. 1623,1629

Downstream Synthesis Route 2

• 484-12-8

• 6619-22-3

Reference: [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 7426 - 7428
[2]Justus Liebigs Annalen der Chemie,1932,vol. 495,p. 187,202
[3]Chemische Berichte,1934,vol. 67,p. 262
[4]Bioorganic and Medicinal Chemistry Letters,1996,vol. 6,p. 1791 - 1794
[5]European Journal of Medicinal Chemistry,2011,vol. 46,p. 4042 - 4049

Downstream Synthesis Route 3

• 484-12-8

• 181303-71-9

Reference: [1]ChemMedChem,2010,vol. 5,p. 598 - 607
[2]European Journal of Medicinal Chemistry,2011,vol. 46,p. 4042 - 4049
[3]Chemische Berichte,1933,vol. 66,p. 754,759

* For details of the synthesis route, please refer to the original source to ensure accuracy.