Methyl 3-Hydroxypropanoate

• CAS: 6149-41-3
• Catalog Number: ACM6149413-1
• Category: Main Products
• Molecular Weight: 104.1
• Molecular Formula: C4H8O3
• Synonyms: Methyl hydracrylate, Hydracrylic acid, methyl ester, Methyl 3-hydroxypropanoate, Methyl beta-hydroxypropionate, Propanoic acid, 3-hydroxy-, methyl ester, MolPort-001-787-796, CID80252, EN002714, EN300-52373, InChI=1/C4H8O3/c1-7-4(6)2-3-5/h5H,2-3H2,1H, 6149-41-3
• IUPAC Name: methyl 3-hydroxypropanoate
• Canonical SMILES: COC(=O)CCO
• InChI Key: RVGLEPQPVDUSOJ-UHFFFAOYSA-N
• Boiling Point: 180.50 °C at 760 mmHg (Predicted)
• Flash Point: 72.6ºC
• Density: 1.089 g/cm³
• Exact Mass: 104.04700
• H-Bond Acceptor: 3
• H-Bond Donor: 1

Case Study

Methyl 3-Hydroxypropanoate for oxidative esterification of 1,3-propanediol

Kotionova, Tatyana, et al. Catalysis letters 142 (2012): 1114-1120.

Oxidative esterification of a series of homologous diols with methanol using molecular oxygen has been investigated using gold, palladium, and gold-palladium catalysts supported on titanium dioxide. The gold-palladium catalyst showed the highest activity, with 1,3-propanediol being the most reactive, while the additional methyl group reduced the reactivity. However, high selectivity towards methyl 3-hydroxypropanoate and 2-methyl-3-hydroxyisobutyric acid could be achieved by single oxidation. Methyl 3-Hydroxypropanoate is the key product in the oxidative esterification of 1,3-propanediol, and its formation is closely related to the activity of the catalysts such as Au-Pd/TiO2. The stability and hydrolysis behavior of this ester affect the final product distribution of the reaction, while side reactions reveal the complexity of the reaction system. These findings are consistent with studies on noble metal-catalyzed oxidative esterification and the formation pathway of 3-hydroxypropanoic acid in biotransformation.
A 50 mL Radleys low-pressure reactor with a maximum operating pressure of 4 bar was used for the oxidative esterification. In the experiment, the reactor was loaded with 1,3-propanediol, 2-methyl-1,3-propanediol or 2,2-dimethyl-1,3-propanediol (1.5 mmol), sodium hydroxide (1.5 mmol, 0.06 g), methanol (7.9 g) and catalyst (substrate/metal molar ratio of 500/1). After the reactor was sealed, it was purged with oxygen three times and pressurized to 3 bar with oxygen; during the entire reaction process, the oxygen inlet remained open so that it could be replenished in time when oxygen was consumed. The reaction mixture was heated to 80°C with stirring at 1000 rpm and cooled to 20°C for sampling periodically. Subsequently, the reactor was filled with oxygen again and reheated to 80°C. Methyl 3-Hydroxypropanoate was detected as a product of the oxidative esterification reaction of 1,3-propanediol.

Study on the synthesis of methyl 3-hydroxypropionate by catalytic hydrogenation

Xiaolong, Fang, et al. 42.5 (2022): 1407.

Ruthenium acetylacetonate and aminophosphine ligands were selected as the catalytic system and applied to the catalytic hydrogenation of dimethyl malonate to prepare methyl 3-hydroxypropionate. Focusing on the catalytic efficiency, the important factors that have a significant impact on the conversion rate of dimethyl malonate and the selectivity of methyl 3-hydroxypropionate, such as ligand structure, dosage, reaction temperature, reaction time, solvent, etc., were discussed. The results show that the catalytic system of ruthenium acetylacetonate and o-diphenylphosphinoaniline ligands can achieve significant catalytic effects. Under the optimal reaction conditions, the catalytic system can also be efficiently applied to the catalytic hydrogenation of some other esters.
A homogeneous catalyst system composed of Ru(acac)3 and o-diphenylphosphinoaniline was used to synthesize methyl 3-hydroxypropionate. The effects of reaction conditions such as ligand dosage, reaction temperature and time, and solvent on the catalytic performance were systematically investigated. The study found that the molar ratio of Ru(acac)3 and o-diphenylphosphinoaniline was 1:2, which was more suitable. In addition, compared with the use of methanol as a solvent, the use of methanol-THF mixed solvent can effectively improve the catalytic hydrogenation performance of the catalytic system. Under the optimized reaction conditions, the DMM conversion rate reached 86%, and the yields of the target products 3-HPM and 1,3-PDO were 75% and 8%, respectively.

Custom Q&A

What is the molecular formula of Methyl 3-Hydroxypropanoate?

The molecular formula of Methyl 3-Hydroxypropanoate is C4H8O3.

What are the synonyms of Methyl 3-Hydroxypropanoate?

The synonyms of Methyl 3-Hydroxypropanoate are Propanoic acid, 3-hydroxy-, methyl ester and Methyl hydracrylate.

What is the molecular weight of Methyl 3-Hydroxypropanoate?

The molecular weight of Methyl 3-Hydroxypropanoate is 104.10 g/mol.

When was Methyl 3-Hydroxypropanoate created?

Methyl 3-Hydroxypropanoate was created on March 27, 2005.

What is the IUPAC name of Methyl 3-Hydroxypropanoate?

The IUPAC name of Methyl 3-Hydroxypropanoate is methyl 3-hydroxypropanoate.

What is the InChI of Methyl 3-Hydroxypropanoate?

The InChI of Methyl 3-Hydroxypropanoate is InChI=1S/C4H8O3/c1-7-4(6)2-3-5/h5H,2-3H2,1H3.

What is the InChIKey of Methyl 3-Hydroxypropanoate?

The InChIKey of Methyl 3-Hydroxypropanoate is RVGLEPQPVDUSOJ-UHFFFAOYSA-N.

What is the Canonical SMILES of Methyl 3-Hydroxypropanoate?

The Canonical SMILES of Methyl 3-Hydroxypropanoate is COC(=O)CCO.

What is the CAS number of Methyl 3-Hydroxypropanoate?

The CAS number of Methyl 3-Hydroxypropanoate is 6149-41-3.

What is the hydrogen bond acceptor count of Methyl 3-Hydroxypropanoate?

The hydrogen bond acceptor count of Methyl 3-Hydroxypropanoate is 3.