Meprednisone

• CAS: 1247-42-3
• Catalog Number: ACM1247423
• Category: Inhibitors
• Molecular Weight: 372.45
• Molecular Formula: C₂₂H₂₈O₅
• Description: Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL .
• Synonyms: BETAPAR; betalone; betapred; bitanisone; deltisonab; betanisona; methylprednisone
• IUPAC Name: (8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
• Canonical SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3C(=O)CC2(C1(C(=O)CO)O)C)C
• InChI Key: PIDANAQULIKBQS-RNUIGHNZSA-N
• Boiling Point: 574.4ºC at 760mmHg
• Melting Point: 204-206ºC
• Flash Point: 315.2ºC
• Density: 1.28g/cm³
• Appearance: white solid
• Storage: 4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light).
• EC Number: 214-996-1
• Exact Mass: 372.19400
• Shipping: Can be shipped at room temperature, where not in use may vary.

Custom Q&A

What is the molecular formula of Meprednisone?

The molecular formula of Meprednisone is C22H28O5.

What is the molecular weight of Meprednisone?

The molecular weight of Meprednisone is 372.5 g/mol.

What is the IUPAC name of Meprednisone?

The IUPAC name of Meprednisone is (8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione.

What is the InChIKey of Meprednisone?

The InChIKey of Meprednisone is PIDANAQULIKBQS-RNUIGHNZSA-N.

What is the canonical SMILES of Meprednisone?

The canonical SMILES of Meprednisone is CC1CC2C3CCC4=CC(=O)C=CC4(C3C(=O)CC2(C1(C(=O)CO)O)C)C.

What is the CAS number of Meprednisone?

The CAS number of Meprednisone is 1247-42-3.

What is the UNII of Meprednisone?

The UNII of Meprednisone is 67U96J8P35.

What is the XLogP3 value of Meprednisone?

The XLogP3 value of Meprednisone is 1.9.

How many hydrogen bond donor counts does Meprednisone have?

Meprednisone has 2 hydrogen bond donor counts.

How many rotatable bond counts does Meprednisone have?

Meprednisone has 2 rotatable bond counts.