L-Histidine methyl ester dihydrochloride

• CAS: 7389-87-9
• Catalog Number: ACM7389879
• Category: Amino Acids
• Molecular Weight: 242.1
• Synonyms: (S)-Histidine methyl ester dihydrochloride, Methyl L-histidinate dihydrochloride
• Canonical SMILES: Cl.Cl.COC(=O)[C@@H](N)Cc1c[nH]cn1
• InChI: 1S/C7H11N3O2.2ClH/c1-12-7(11)6(8)2-5-3-9-4-10-5;;/h3-4,6H,2,8H2,1H3,(H,9,10);2*1H/t6-;;/m0../s1
• InChI Key: DWAYENIPKPKKMV-ILKKLZGPSA-N
• Melting Point: 207 ℃(dec.) (lit.)
• Application: L-Histidine methyl ester dihydrochloride can be used as a reactant to synthesize:; Imidazopyridine derivatives by Pictet-Spegler reaction with different aldehydes.; A metal-chelating ligand, N-methacryloyl-(l)-histidine methyl ester by reacting with methacryloyl chloride.; Zwitterionic polypeptide derivative by amidation reaction with poly (α,β-L-aspartic acid).
• Assay: 0.97
• Beilstein: 3572009
• Color: white
• EC Number: 230-973-9
• Form: Company; About Us; Responsibility; Events; Press Releases; Programs; Careers; Offices
• MDL Number: MFCD00012701
• NACRES: NA.22
• Optical Activity: [α]20/D +9.0°, c = 2 in H2O
• PubChem ID: 24895465
• Quality Level: 100
• Reaction Suitability: reaction type: solution phase peptide synthesis
• Storage Temperature: 2-8℃

Synthetic Use

Downstream Synthesis Route 1

• 64017-81-8
• 7389-87-9

• 2140-53-6
• 1246364-63-5
• 1246364-64-6
• 305-84-0

Reference: [1] Advanced Synthesis and Catalysis, 2010, vol. 352, # 2-3, p. 407 - 415

Downstream Synthesis Route 2

• 65-86-1
• 7389-87-9

• 78664-77-4

Reference: [1]Acta Chimica Hungarica,1992,vol. 129,p. 871 - 877

Downstream Synthesis Route 3

• 67-56-1
• 645-35-2

• 4467-54-3

Reference: [1]Tetrahedron Asymmetry,2008,vol. 19,p. 273 - 278
[2]Patent: US2009/93642,2009,A1 .Location in patent: Page/Page column 6; 7

* For details of the synthesis route, please refer to the original source to ensure accuracy.