L-Histidine

• CAS: 71-00-1
• Catalog Number: ACM71001-2
• Category: Amino Acids
• Molecular Weight: 155.15
• Molecular Formula: C6H9N3O2
• Description: L-Histidine is a proteinogenic amino acid and an essential amino acid required for histamine production. This positively charged amino acid is vital for growth, tissue repair, myelin sheath maintenance, and histamine synthesis. Histamine plays critical roles in immunity, gastric secretion, and more. L-Histidine is essential for blood cell production and tissue protection against radiation and heavy metals. L-Histidine plays a role as a metabolite and also acts as a cofactor in enzyme protection during protein synthesis. It is an L-enantiomer of histidine and is necessary for histamine synthesis and human development. L-Histidine finds applications in cell culture, metabolomics and biochemical research.
• Synonyms: (S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773
• Canonical SMILES: N[C@@H](Cc1c[nH]cn1)C(O)=O
• InChI: 1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
• InChI Key: HNDVDQJCIGZPNO-YFKPBYRVSA-N
• Boiling Point: 458.9±35.0 ℃at 760 mmHg
• Melting Point: 282 ℃(dec.) (lit.)
• Flash Point: 231.3±25.9 ℃
• Density: 1.4±0.1 g/cm³
• Solubility: H2O: 50 mg/mL
• Application: L-histidine has been used as a component in agar plates containing 5-fluorocytosine (5-FC) for the selection of yeast transformants. It has also been used as a component of adult mouse keratinocyte growth medium.
• Assay: 98.5-101.0%
• Beilstein: 84088
• Biochem Physiol Actions: L-Histidine is an essential amino acid that binds to metal ions and may aid in the transport of copper. Histidine is widely present at the active sites of enzymes. It also has a role in binding of heme groups, macromolecules and phosphate groups in the binding sites of proteins.
• Biological Source: non-animal source
• Color: white to off-white
• EC Number: 200-745-3
• Exact Mass: 155.069473
• Feature: Can be used in Metabolomics and Biochemical research; High-quality compound suitable for multiple research applications
• Form: powder
• Gene Information: human CA1(759), CA2(760)
• Impurity Content: endotoxin, tested
• LogP: -1.26
• MDL Number: MFCD00064315
• NACRES: NA.26
• PubChem ID: 24895728
• Quality Level: 300
• Refractive Index: 1.615
• Storage Temperature: 2-8℃
• Technique: cell culture | mammalian: suitable
• Vapor Pressure: 0.0±1.2 mmHg at 25℃

Synthetic Use

Upstream Synthesis Route 1

• 4998-57-6

• 71-00-1
• 351-50-8

Reference: [1]Journal of the Chemical Society,1911,vol. 99,p. 1391

Downstream Synthesis Route 1

• 71-00-1

• 4998-57-6

Reference: [1] Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1912, vol. 77, p. 437,438
[2] Journal of Biological Chemistry, 1936, vol. 115, p. 93,97

Downstream Synthesis Route 2

• 71-00-1

• 51-45-6
• 4998-57-6

Reference: [1] Journal of the Chemical Society, 1911, vol. 99, p. 344

Downstream Synthesis Route 3

• 71-00-1

• 4998-57-6

Reference: [1] Bulletin of the Chemical Society of Japan, 1991, vol. 64, # 12, p. 3741 - 3742

Downstream Synthesis Route 4

• 71-00-1

• 1074-59-5

Reference: [1]Hoppe-Seyler's Zeitschrift fur Physiologische Chemie,1910,vol. 65,p. 508

Downstream Synthesis Route 5

• 71-00-1

• 1074-59-5

Reference: [1]Journal of the Chemical Society,1911,vol. 99,p. 344

* For details of the synthesis route, please refer to the original source to ensure accuracy.