JYN42346

• CAS: 1903742-34-6
• Catalog Number: ACM1903742346
• Category: Inhibitors
• Molecular Weight: 574.44
• Molecular Formula: C27H24BrN7O3
• Description: JYN42346, also known as Complement factor D-IN-2, is an inhibitor of complement factor D. JYN42346 targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. JYN42346 can be used for the research of autoimmune diseases. JYN42346 was first reported in patent WO2015130838A1 (compound 190). .
• Synonyms: Complement factor D-IN-2; JYN42346; JYN 42346; JYN-42346
• IUPAC Name: (1R,3S,5R)-2-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide
• Canonical SMILES: O=C([C@H]1N(C(CN2N=C(C(C)=O)C3=C2C=CC(C4=CN=C(C)N=C4)=C3)=O)[C@]5([H])C[C@]5([H])C1)NC6=NC(Br)=CC=C6
• InChI: InChI=1S/C27H24BrN7O3/c1-14(36)26-19-8-16(18-11-29-15(2)30-12-18)6-7-20(19)34(33-26)13-25(37)35-21-9-17(21)10-22(35)27(38)32-24-5-3-4-23(28)31-24/h3-8,11-12,17,21-22H,9-10,13H2,1-2H3,(H,31,32,38)/t17-,21-,22+/m1/s1
• InChI Key: JLRVDNFYMDBUJT-YHYVQYDKSA-N
• Solubility: To be determined
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: To be determined
• Elemental Analysis: C, 56.45; H, 4.21; Br, 13.91; N, 17.07; O, 8.36
• Exact Mass: 573.1124
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).