JMS-17-2

• CAS: 1380392-05-1
• Catalog Number: ACM1380392051
• Category: Antagonists
• Molecular Weight: 419.95
• Molecular Formula: C25H26ClN3O
• Description: JMS-17-2 is a potent and selective antagonist of CX3CR1.
• Synonyms: JMS-17-2; JMS172; JMS 17 2; JMS17-2; JMS-172; JMS 17-2; JMS-17 2
• IUPAC Name: 5-(3-(4-(4-Chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one
• Canonical SMILES: O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4
• InChI: InChI=1S/C25H26ClN3O/c26-21-10-8-19(9-11-21)20-12-17-27(18-13-20)14-4-16-29-23-6-2-1-5-22(23)28-15-3-7-24(28)25(29)30/h1-3,5-11,15,20H,4,12-14,16-18H2
• InChI Key: WOSMCMULWWHMIV-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >3 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 71.50; H, 6.24; Cl, 8.44; N, 10.01; O, 3.81
• Exact Mass: 419.1764
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: This study hypothesized that contact-independent proliferation might be more sensitive to CX3CR1 inhibition, so this study performed soft agar growth assays of PDAC cells with 21-26 d exposure to JMS-17-2. The small molecule antagonist potently inhibited colony formation of both AsPC-1 and MIAPaCa-2 cells with as little as 1 nM exposure (Fig. 4A and B).; Reference: Biochem Biophys Res Commun. 2018 Jan 15;495(3):2264-2269. https://pubmed.ncbi.nlm.nih.gov/29274778/
• In Vivo Activity: These experiments showed that, in contrast to control animals presenting multiple tumors both in the skeleton and visceral sites, seven of the eight animals that received cancer cells pre-incubated with JMS-17-2 were found free of tumors (Fig. 4A and B). Notably, these animals were also found devoid of microscopic tumor foci and DTCs when inspected for fluorescent signals with multispectral microscopy-based imaging of frozen tissue sections (Fig. 4C).; Reference: Mol Cancer Res. 2016 Jun;14(6):518-27. https://pubmed.ncbi.nlm.nih.gov/27001765/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).