Iberdomide

• CAS: 1323403-33-3
• Catalog Number: ACM1323403333
• Category: Others
• Molecular Weight: 449.50
• Molecular Formula: C25H27N3O5
• Description: Iberdomide, also known as CC-220, is potentially for the treatment of systemic lupus erythematosus. Iberdomide significantly reduced Ikaros and Aiolos protein levels in B cells, T cells and monocytes. In SLE PBMC cultures, iberdomide inhibited anti-dsDNA and anti-phospholipid autoantibody production (IC50 ≈10 nM).
• Synonyms: CC-220; CC220; CC 220; Iberdomide
• IUPAC Name: (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
• Canonical SMILES: O=C([C@@H](N(CC1=C2C=CC=C1OCC3=CC=C(CN4CCOCC4)C=C3)C2=O)CC5)NC5=O
• InChI: InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1
• InChI Key: IXZOHGPZAQLIBH-NRFANRHFSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 1560678-63-8 (HCl); 1323403-33-3 (free base)
• Biological Target: Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 of ~150 nM for cereblon-binding affinity.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 66.80; H, 6.05; N, 9.35; O, 17.80
• Exact Mass: 449.1951
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: Iberdomide equally induced PBMC-mediated killing of both parental MM1.S cells and MM1.S/PR cells.; Reference: Leukemia. 2020 Apr;34(4):1197-1201. https://pubmed.ncbi.nlm.nih.gov/31719682/
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).