2-Hydroxychalcone

• CAS: 644-78-0
• Catalog Number: ACM644780-1
• Category: Inhibitors
• Molecular Weight: 224.25
• Molecular Formula: C15H12O2
• Description: 2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB.
• IUPAC Name: (E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
• Canonical SMILES: C1=CC=C(C=C1)C(=O)C=CC2=CC=CC=C2O
• InChI: InChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)10-11-15(17)12-6-2-1-3-7-12/h1-11,16H/b11-10+
• InChI Key: UDOOPSJCRMKSGL-ZHACJKMWSA-N
• Appearance: Solid
• Storage: 4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Complexity: 277
• Covalently-Bonded Unit Count: 1
• EC Number: 211-422-1
• Exact Mass: 224.08373g/mol
• Formal Charge: 0
• H-Bond Acceptor: 2
• H-Bond Donor: 1
• Heavy Atom Count: 17
• Monoisotopic Mass: 224.08373g/mol
• NSC Number: 640539;170281;37432
• Rotatable Bond Count: 3
• Shipping: Can be shipped at room temperature, where not in use may vary.
• XLogP3: 3.3

Synthetic Use

Downstream Synthesis Route 1

• 644-78-0
• 1672-50-0

• 135039-27-9

Reference: [1]Chemistry of Heterocyclic Compounds,1991,vol. 27,p. 205 - 210
Khimiya Geterotsiklicheskikh Soedinenii,1991,p. 250 - 255

Downstream Synthesis Route 2

• 644-78-0

• 75630-71-6

Reference: [1]Litkei, Gyoergy; Gulacsi, Katalin; Antus, Sandor; Dinya, Zoltan
[Synthetic Communications, 1996, vol. 26, # 16, p. 3061 - 3074]
[2]Litkei, Gyoergy; Gulacsi, Katalin; Antus, Sandor; Dinya, Zoltan
[Synthetic Communications, 1996, vol. 26, # 16, p. 3061 - 3074]
[3]Mangini
[Gazzetta Chimica Italiana, 1937, vol. 67, p. 39,43]

* For details of the synthesis route, please refer to the original source to ensure accuracy.