HSD-016

• CAS: 946396-92-5
• Catalog Number: ACM946396925
• Category: Inhibitors
• Molecular Weight: 514.46
• Molecular Formula: C21H21F7N2O3S
• Description: HSD-016 is a potent, selective, and efficacious 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor.
• Synonyms: HSD-016; HSD 016; HSD016; HSD-16; HSD 16; HSD16
• IUPAC Name: (R)-1,1,1-trifluoro-2-(3-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)phenyl)propan-2-ol
• Canonical SMILES: O[C@](C(F)(F)F)(C)C1=CC=CC(S(=O)(N2[C@H](C)CN(C3=CC=C(F)C=C3C(F)(F)F)CC2)=O)=C1
• InChI: InChI=1S/C21H21F7N2O3S/c1-13-12-29(18-7-6-15(22)11-17(18)20(23,24)25)8-9-30(13)34(32,33)16-5-3-4-14(10-16)19(2,31)21(26,27)28/h3-7,10-11,13,31H,8-9,12H2,1-2H3/t13-,19-/m1/s1
• InChI Key: ZWASRJHIEFYJGL-BFUOFWGJSA-N
• Solubility: To be determined
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: (R)-1,1,1-trifluoro-2-(3-((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)phenyl)propan-2-ol (HSD-016) was discovered to be a potent, selective, and efficacious 11β-HSD1 inhibitor and advanced as a clinical candidate.
• Drug Formulation: To be determined
• Elemental Analysis: C, 49.03; H, 4.11; F, 25.85; N, 5.45; O, 9.33; S, 6.23
• Exact Mass: 514.1161
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: TBD
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).